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CAS 165800-07-7

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Zoledronate disodium tetrahydrate

Description:
Zoledronate disodium tetrahydrate is a bisphosphonate compound primarily used in the treatment of bone disorders, such as osteoporosis and Paget's disease, as well as in the management of bone metastases in cancer patients. It functions by inhibiting osteoclast-mediated bone resorption, thereby helping to maintain bone density and strength. The substance is characterized by its disodium salt form, which enhances its solubility in aqueous solutions, making it suitable for intravenous administration. As a tetrahydrate, it contains four molecules of water, which are integral to its crystalline structure and stability. Zoledronate disodium tetrahydrate is typically administered in a clinical setting, and its pharmacokinetics involve a prolonged half-life, allowing for less frequent dosing compared to other bisphosphonates. Common side effects may include flu-like symptoms, renal impairment, and gastrointestinal disturbances. Its chemical structure includes a central phosphorus atom bonded to carbon and oxygen, characteristic of bisphosphonates, which contributes to its efficacy in inhibiting bone resorption.
Formula:C5H16N2Na2O11P2
InChI:InChI=1/C5H10N2O7P2.2Na/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);;/q;2*+1/p-2
SMILES:c1cn(CC(O)(P(=O)(O)O)P(=O)(O)O)cn1.[Na].[Na]
Synonyms:
  • Zoledronic Acid, Disodium Salt, Tetrahydrate
  • Cgp-42446A
  • Zoledronate Disodium, CGP-42446A
  • (1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid disodium salt tetrahydrate
  • disodium [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis[hydrogen (phosphonate)]
  • ZOLEDRONATE DISODIUM, TETRAHYDRATE
  • Sodium (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate tetrahydrate
  • Disodium salt tetrahydrate
  • Zoledronate DisodiuM (C5H8N2Na2O7P24H2O)
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