CAS 165893-48-1

H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH

Description:

The chemical substance identified as H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH, with the CAS number 165893-48-1, is a peptide composed of multiple arginine (Arg) residues. This structure indicates that it is a polyarginine, which is a type of cationic peptide known for its positive charge due to the presence of multiple guanidinium groups in the arginine side chains. Polyarginines are often studied for their biological activities, including their ability to facilitate cellular uptake of various molecules, including nucleic acids, due to their interaction with negatively charged cellular membranes. They can also exhibit antimicrobial properties and are of interest in drug delivery systems. The presence of the hydroxyl group (OH) at the terminal end suggests that it may have additional solubility or reactivity characteristics. Overall, polyarginines are significant in biochemistry and molecular biology, particularly in the development of therapeutic agents and delivery vehicles.

Formula: C₄₂H₈₆N₂₈O₈

Synonyms:

• Arg-Arg-Arg-Arg-Arg-Arg-Arg

H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH

CAS: 165893-48-1

Arginine oligomers as heptaarginine, either alone or when conjugated to therapeutic agents or large biopolymers, have been shown to cross readily a variety of biological membranes (e.g. lipid bilayers and epithelial tissue). The importance of the guanidinium group in transport was supported by the observation that short oligomers of arginine entered cells far more rapidly than the corresponding oligomers of either lysine, histidine, ornithine, or citrulline.

Formula: C₄₂H₈₆N₂₈O₈

Purity: 97.1%

Color and Shape: White Powder

Molecular weight: 1111.33

Ref: 01-4041657

H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH trifluoroacetate salt

CAS: 165893-48-1

The Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH trifluoroacetate salt is a biologically active form of arginine. It has been shown to inhibit the activity of both NS3 protease and NS4A protease from the hepatitis C virus (HCV). It also inhibits tumor cell growth in vitro, which may be due to its ability to upregulate epidermal growth factor receptor (EGFR) expression on tumor cells. The Arg-Arg-Arg-Arg-Arg-Arg-Arghydrogen trifluoroacetate salt is an inhibitor of estrogen receptor modulators that are used as therapeutic agents for breast cancer.

Formula: C₄₂H₈₆N₂₈O₈

Purity: Min. 95%

Molecular weight: 1,111.32 g/mol

Ref: 3D-FA109644