CAS 166247-63-8

7-DEAZA-7-IODO-2'-DEOXYADENOSINE

Description:

7-Deaza-7-iodo-2'-deoxyadenosine is a modified nucleoside analog that features a deaza substitution at the 7-position of the adenine base, along with an iodine atom at the same position. This structural modification enhances its stability and alters its biological activity compared to natural nucleosides. The compound is characterized by its ability to incorporate into nucleic acids, potentially affecting DNA and RNA synthesis and function. It is often studied for its implications in molecular biology and medicinal chemistry, particularly in the context of antiviral and anticancer research. The presence of the iodine atom may also facilitate imaging studies or serve as a marker in biochemical assays. As a nucleoside analog, it can interfere with normal cellular processes, making it a valuable tool for investigating nucleic acid metabolism and function. Its unique properties make it a subject of interest in the development of therapeutic agents and in the study of nucleic acid interactions.

Synonyms:

• 4-Amino-5-iodo-7-(2-deoxy--D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-

CAS: 166247-63-8

Formula: C₁₁H₁₃IN₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 376.1504

Ref: IN-DA001WLG

7-Deaza-2'-deoxy-7-iodoadenosine

CAS: 166247-63-8

7-Deaza-2'-deoxy-7-iodoadenosine

Purity: 98%

Molecular weight: 376.15g/mol

Ref: 54-OR72933

7-Deaza-2'-deoxy-7-iodoadenosine

CAS: 166247-63-8

7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine.

Formula: C₁₁H₁₃IN₄O₃

Color and Shape: Solid

Molecular weight: 376.15

Ref: TM-T39141

5-Iodo-2'-deoxytubercidin

CAS: 166247-63-8

Formula: C₁₁H₁₃IN₄O₃

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 376.15

Ref: 3B-D6015

7-Deaza-2'-deoxy-7-iodoadenosine

CAS: 166247-63-8

7-Deaza-2'-deoxy-7-iodoadenosine (7DADI) is a modified nucleoside that has antiviral and anticancer properties. It is synthesized by the reaction of 2'-deoxyadenosine with iodine in the presence of an activator such as sodium hypochlorite. 7DADI binds to ribonucleosides, forming a phosphoramidate bond at the 3' position, which leads to inhibition of viral RNA synthesis and DNA replication. This drug also inhibits the growth of cancer cells by inhibiting DNA synthesis and protein synthesis. 7DADI is novel because it is not found in nature or produced by any other organism.

Formula: C₁₁H₁₃IN₄O₃

Purity: Min. 98 Area-%

Molecular weight: 376.16 g/mol

Ref: 3D-D-0050

7-Deaza-2'-deoxy-7-iodoadenosine

CAS: 166247-63-8

7-Deaza-2'-deoxy-7-iodoadenosine is an oligomer with a stabilized backbone that has been shown to inhibit the growth of bacteria in vitro. It binds to DNA and prevents RNA synthesis. 7-Deaza-2'-deoxy-7-iodoadenosine is a synthetic nucleotide analogue that is used as a probe for mapping RNA sequences and as an inhibitor of bacterial growth. This compound is also used in the synthesis of oligodeoxynucleotides because it has a high affinity for guanine residues, which can be incorporated into the oligonucleotide chain by chemical ligation. The octameric form of 7-deaza-2'-deoxyadenosine is most active against bacterial cells.

Formula: C₁₁H₁₃IN₄O₃

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 376.16 g/mol

Ref: 3D-ND06190

(2R,3S,5R)-5-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

CAS: 166247-63-8

Formula: C₁₁H₁₃IN₄O₃

Purity: 98%

Molecular weight: 376.154

Ref: 10-F543826

5-Iodo-2’-deoxytubercidin

Controlled Product

CAS: 166247-63-8

Stability Light Sensitive
Applications 5-Iodo-2’-deoxytubercidin is a derivative of 7-Iodo-7-deazadenine designed to be incorporated into DNA by primers extension by using Vent(exo-) polymerase. Possesses photophysical properties.
References Macickova-Cahova, H., et al.: Chem. Eur. J., 17, 5833-5841 (2011); Saito, Y., et al.: Tetrahedron Lett., 52, 4726-4729 (2011)

Formula: C₁₁H₁₃IN₄O₃

Color and Shape: Neat

Molecular weight: 376.15

Ref: TR-I705030