CAS 166518-60-1

Avasimibe

Description:

Avasimibe is a synthetic organic compound primarily known for its role as a cholesterol-lowering agent. It functions as an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), an enzyme involved in the esterification of cholesterol, which is crucial for lipid metabolism. The inhibition of ACAT by Avasimibe leads to a reduction in cholesterol absorption and promotes the clearance of cholesterol from the bloodstream. This compound is characterized by its specific molecular structure, which includes a distinct arrangement of functional groups that contribute to its biological activity. Avasimibe has been studied for its potential therapeutic applications in managing hyperlipidemia and atherosclerosis. Additionally, it has been evaluated in various preclinical and clinical studies to assess its efficacy and safety profile. However, its development has faced challenges, and it has not been widely adopted in clinical practice. Overall, Avasimibe represents an important example of targeted pharmacological intervention in lipid metabolism.

Formula: C₂₉H₄₃NO₄S

InChI: InChI=1S/C29H43NO4S/c1-17(2)22-14-25(20(7)8)27(26(15-22)21(9)10)16-28(31)30-35(32,33)34-29-23(18(3)4)12-11-13-24(29)19(5)6/h11-15,17-21H,16H2,1-10H3,(H,30,31)

InChI key: InChIKey=PTQXTEKSNBVPQJ-UHFFFAOYSA-N

SMILES: C(C(NS(OC1=C(C(C)C)C=CC=C1C(C)C)(=O)=O)=O)C2=C(C(C)C)C=C(C(C)C)C=C2C(C)C

Synonyms:

• ((2,4,6-Tris(1-Methylethyl)Phenyl)Acetyl)Sulfamicacid2,6-Bis(1-Methylethyl)Phenylester
• 2,6-Di(Propan-2-Yl)Phenyl {[2,4,6-Tri(Propan-2-Yl)Phenyl]Acetyl}Sulfamate
• 2,6-Diisopropylphenyl (2-(2,4,6-triisopropylphenyl)acetyl)sulfamate
• Avasimin
• Ci 1011
• N-(2,6-Dipropan-2-Ylphenoxy)Sulfonyl-2-(2,4,6-Tripropan-2-Ylphenyl)Acetamide
• N-[(2,6-Diisopropylphenoxy)Sulfonyl]-2-(2,4,6-Triisopropylphenyl)Acetamide
• Pd 148515
• Sulfamic acid, N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester
• Sulfamic acid, [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester
• Avasimibe

Sulfamic acid, N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester

CAS: 166518-60-1

Formula: C₂₉H₄₃NO₄S

Purity: 99%

Color and Shape: Solid

Molecular weight: 501.7210

Ref: IN-DA001WS5

Avasimibe

CAS: 166518-60-1

Formula: C₂₉H₄₃NO₄S

Molecular weight: 501.72

Ref: 7W-GP7587

Avasimibe

CAS: 166518-60-1

Avasimibe

Purity: ≥98%

Molecular weight: 501.72g/mol

Ref: 54-BUP13680

Avasimibe

CAS: 166518-60-1

Formula: C₂₉H₄₃NO₄S

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 501.73

Ref: 3B-A3594

Avasimibe

CAS: 166518-60-1

Avasimibe (PD-148515): Oral ACAT inhibitor, prevents arterial cholesterol buildup; IC50: 3.3 μM. Hinders CYP2C9/1A2/2C19; IC50: 2.9/13.9/26.5 μM.

Formula: C₂₉H₄₃NO₄S

Purity: 98.39% - 99.91%

Color and Shape: Solid

Molecular weight: 501.72

Ref: TM-T2753

Avasimibe

CAS: 166518-60-1

Applications Avasimibe is a selective inhibitor of Cholesterol Acyltransferase 1 and CYP2C9. Avasimibe is known to induce apoptosis of glioma cell lines as a model of glioblastoma.
References Bemlih, S., et al.: Cancer. BIol. Therap., 9, 1025 (2010); Fahmi, O.A., et al.: Drug. Meta. Disp. 38, 1605 (2010);

Formula: C₂₉H₄₃NO₄S

Color and Shape: White Solid

Molecular weight: 501.72

Ref: TR-A794680

Sulfamic acid, N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester

CAS: 166518-60-1

Purity: 99%

Molecular weight: 501.730011

Ref: 10-F862013