CAS 16662-47-8

(±)-Gallopamil

Description:

(±)-Gallopamil is a chemical compound classified as a calcium channel blocker, primarily used in the treatment of cardiovascular conditions such as hypertension and angina. It is a derivative of the phenylalkylamine class and exhibits a chiral nature, meaning it exists in two enantiomeric forms. The compound functions by inhibiting the influx of calcium ions through L-type calcium channels, leading to vasodilation and reduced cardiac contractility. This mechanism helps to lower blood pressure and alleviate chest pain associated with angina. In addition to its cardiovascular effects, (±)-Gallopamil has been studied for its potential neuroprotective properties. The substance is typically administered in its racemic form, which contains equal amounts of both enantiomers. Its pharmacokinetics include moderate absorption and metabolism, with a half-life that allows for once or twice daily dosing. Safety and efficacy profiles are well-documented, although side effects may include dizziness, headache, and gastrointestinal disturbances. As with any medication, it is essential to use (±)-Gallopamil under medical supervision to manage potential interactions and contraindications.

Formula: C₂₈H₄₀N₂O₅

InChI: InChI=1S/C28H40N2O5/c1-20(2)28(19-29,22-17-25(33-6)27(35-8)26(18-22)34-7)13-9-14-30(3)15-12-21-10-11-23(31-4)24(16-21)32-5/h10-11,16-18,20H,9,12-15H2,1-8H3

InChI key: InChIKey=XQLWNAFCTODIRK-UHFFFAOYSA-N

SMILES: C(CCCN(CCC1=CC(OC)=C(OC)C=C1)C)(C(C)C)(C#N)C2=CC(OC)=C(OC)C(OC)=C2

Synonyms:

• (±)-Methoxyverapamil
• 5-((3,4-Dimethoxyphenethyl)methylamino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)valeronitrile
• 5-{[2-(3,4-Dimethoxyphenyl)Ethyl](Methyl)Amino}-2-(Propan-2-Yl)-2-(3,4,5-Trimethoxyphenyl)Pentanenitrile
• Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4,5-trimethoxy-alpha-(1-methylethyl)-
• Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)-
• Compound D 600
• D 600
• D 600 (vasodilator)
• Gallopamil [INN:BAN]
• Gallopamillum
• Gallopamillum [INN-Latin]
• Galopamilo
• Galopamilo [INN-Spanish]
• Lu 30-029
• Unii-39Wpc8Jhr8
• Valeronitrile, 5-[(3,4-dimethoxyphenethyl)methylamino]-2-isopropyl-2-(3,4,5-trimethoxyphenyl)-
• dl-D 600
• α-Isopropyl-α-[(N-methyl-N-homoveratryl)-γ-aminopropyl]-3,4,5-trimethoxyphenylacetonitrile
• α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)benzeneacetonitrile

Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)-

CAS: 16662-47-8

Formula: C₂₈H₄₀N₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 484.6276

Ref: IN-DA001WVF

Gallopamil

CAS: 16662-47-8

Gallopamil

Purity: ≥98%

Molecular weight: 484.63g/mol

Ref: 54-BUP12789

(±)-Methoxyverapamil hydrochloride

CAS: 16662-47-8

Formula: C₂₈H₄₀N₂O₅·HCl

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 521.09

Ref: 7W-GK4905

(+/-)-Methoxyverapamil

Controlled Product

CAS: 16662-47-8

Formula: C₂₈H₄₀N₂O₅

Color and Shape: Neat

Molecular weight: 484.628

Ref: TR-M271768

Gallopamil

CAS: 16662-47-8

Gallopamil blocks acid secretion (IC50: 10.9 μM), acts as antiarrhythmic, vasodilator, and is a methoxy Verapamil derivative.

Formula: C₂₈H₄₀N₂O₅

Purity: 99.85%

Color and Shape: Solid

Molecular weight: 484.63

Ref: TM-T11353