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CAS 16662-47-8

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(±)-Gallopamil

Description:
(±)-Gallopamil is a chemical compound classified as a calcium channel blocker, primarily used in the treatment of cardiovascular conditions such as hypertension and angina. It is a derivative of the phenylalkylamine class and exhibits a chiral nature, meaning it exists in two enantiomeric forms. The compound functions by inhibiting the influx of calcium ions through L-type calcium channels, leading to vasodilation and reduced cardiac contractility. This mechanism helps to lower blood pressure and alleviate chest pain associated with angina. In addition to its cardiovascular effects, (±)-Gallopamil has been studied for its potential neuroprotective properties. The substance is typically administered in its racemic form, which contains equal amounts of both enantiomers. Its pharmacokinetics include moderate absorption and metabolism, with a half-life that allows for once or twice daily dosing. Safety and efficacy profiles are well-documented, although side effects may include dizziness, headache, and gastrointestinal disturbances. As with any medication, it is essential to use (±)-Gallopamil under medical supervision to manage potential interactions and contraindications.
Formula:C28H40N2O5
InChI:InChI=1S/C28H40N2O5/c1-20(2)28(19-29,22-17-25(33-6)27(35-8)26(18-22)34-7)13-9-14-30(3)15-12-21-10-11-23(31-4)24(16-21)32-5/h10-11,16-18,20H,9,12-15H2,1-8H3
InChI key:InChIKey=XQLWNAFCTODIRK-UHFFFAOYSA-N
SMILES:C(CCCN(CCC1=CC(OC)=C(OC)C=C1)C)(C(C)C)(C#N)C2=CC(OC)=C(OC)C(OC)=C2
Synonyms:
  • (±)-Methoxyverapamil
  • 5-((3,4-Dimethoxyphenethyl)methylamino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)valeronitrile
  • 5-{[2-(3,4-Dimethoxyphenyl)Ethyl](Methyl)Amino}-2-(Propan-2-Yl)-2-(3,4,5-Trimethoxyphenyl)Pentanenitrile
  • Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4,5-trimethoxy-alpha-(1-methylethyl)-
  • Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4,5-trimethoxy-α-(1-methylethyl)-
  • Compound D 600
  • D 600
  • D 600 (vasodilator)
  • Gallopamil [INN:BAN]
  • Gallopamillum
  • See more synonyms
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