CAS 166663-25-8

Anidulafungin

Description:

Anidulafungin is a synthetic antifungal agent belonging to the echinocandin class, primarily used for the treatment of invasive fungal infections, particularly those caused by Candida species and Aspergillus. It functions by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the fungal cell wall, thereby compromising the integrity of the cell wall and leading to cell lysis. Anidulafungin is characterized by its high stability in solution, which allows for once-daily dosing, and it is administered intravenously. The compound is generally well-tolerated, with a favorable safety profile, although potential side effects may include gastrointestinal disturbances and liver enzyme elevations. Its pharmacokinetics are notable for a long half-life, which supports its dosing regimen. Anidulafungin is particularly valuable in clinical settings for patients who are immunocompromised or have underlying conditions that predispose them to fungal infections. Overall, its unique mechanism of action and pharmacological properties make it an important option in antifungal therapy.

Formula: C₅₈H₇₃N₇O₁₇

InChI: InChI=1/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42)57(80)44(30(3)66)60-52(41)75/h8-23,29-31,39,41-50,54,66-73,77H,5-7,24-28H2,1-4H3,(H,59,74)(H,60,75)(H,61,78)(H,62,76)(H,63,79)/t29-,30+,31+,39+,41-,42-,43+,44-,45-,46-,47-,48-,49-,50-,54+/m0/s1

Synonyms:

• Echinocandin B, 1-(4R,5R)-4,5-dihydroxy-N2-4-(pentyloxy)1,1:4,1-terphenyl-4-ylcarbonyl-L-ornithine-
• N-{(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-4''-(pentyloxy)-1,1':4',1''-terphenyl-4-carboxamide
• Echinocandin B, 1-[(4R,5R)-4,5-dihydroxy-N2-[[4''-(pentyloxy)[1,1':4',1''-terphenyl]-4-yl]carbonyl]-L-ornithine]-
• Eraxis
• Ly 303366

Echinocandin B, 1-[(4R,5R)-4,5-dihydroxy-N2-[[4''-(pentyloxy)[1,1':4',1''-terphenyl]-4-yl]carbonyl]-L-ornithine]-

CAS: 166663-25-8

Formula: C₅₈H₇₃N₇O₁₇

Purity: %

Color and Shape: Solid

Molecular weight: 1140.2369

Ref: IN-DA001WVR

Anidulafungin

CAS: 166663-25-8

Formula: C₅₈H₇₃N₇O₁₇

Molecular weight: 1140.25

Ref: 4Z-PA-200001

Anidulafungin

CAS: 166663-25-8

Formula: C₅₈H₇₃N₇O₁₇

Purity: ≥ 97.0%

Color and Shape: White to off-white or beige powder

Molecular weight: 1140.24

Ref: 7W-GK5935

Anidulafungin

CAS: 166663-25-8

Anidulafungin

Formula: C₅₈H₇₃N₇O₁₇

Purity: ≥98%

Color and Shape: Solid

Molecular weight: 1140.24

Ref: 54-BUP13095

Anidulafungin-d11

CAS: 166663-25-8

Formula: C₅₈H₆₂N₇O₁₇D₁₁

Molecular weight: 1151.33

Ref: 4Z-PA-200002

Anidulafungin

CAS: 166663-25-8

N-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,12,15-tetrahydroxy-6,20-bis((R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacycl

Formula: C₅₈H₇₃N₇O₁₇

Purity: 98+%

Molecular weight: 1140.24

Ref: IN-DG630424

Anidulafungin

CAS: 166663-25-8

Anidulafungin (Ecalta) (LY303366) is an echinocandin derivative used as an antifungal drug. It inhibits glucan synthase activity.

Formula: C₅₈H₇₃N₇O₁₇

Purity: 99.15% - >99.99%

Color and Shape: White Solid

Molecular weight: 1140.24

Ref: TM-T6088

Anidulafungin

CAS: 166663-25-8

Formula: C₅₈H₇₃N₇O₁₇

Molecular weight: 1140.25

Ref: ST-EA-CP-A200000

Anidulafungin

CAS: 166663-25-8

Applications Anidulafungin, is a semisynthetic echinocandin that inhibits glucan synthase, an enzyme important in the formation of (1→3)-β-D-glucan, a major fungal cell wall component, and thus is used as antifungal drug.
References Denning, D. W., et al.: J. Antimicrob. Chemother, 40, 611 (1997); Vazquez, J. A., et al.: Clin. Ther., 27(6), 657 (2005);

Formula: C₅₈H₇₃N₇O₁₇

Color and Shape: Neat

Molecular weight: 1140.24

Ref: TR-A673000

Anidulafungin

CAS: 166663-25-8

Anti-fungal; glucan synthase inhibitor

Formula: C₅₈H₇₃N₇O₁₇

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 1,140.24 g/mol

Ref: 3D-FA16270

Anidulafungin-[13C6]

CAS: 166663-25-8

Ref: BE-MC-7747

Anidulafungin

CAS: 166663-25-8

Ref: BE-RMCP467000

Anidulafungin-d11

Controlled Product

CAS: 166663-25-8

Formula: C₅₈D₁₁H₆₂N₇O₁₇

Color and Shape: Neat

Molecular weight: 1151.305

Ref: TR-A673002