CAS 1670-87-7

Indole-5-carboxamide

Description:

Indole-5-carboxamide is an organic compound characterized by its indole structure, which consists of a fused benzene and pyrrole ring. The presence of a carboxamide functional group at the 5-position of the indole ring imparts specific chemical properties, including the ability to participate in hydrogen bonding due to the amide nitrogen and carbonyl oxygen. This compound is typically a white to off-white solid and is soluble in polar solvents such as water and alcohols, which is influenced by the polar nature of the carboxamide group. Indole-5-carboxamide is of interest in various fields, including medicinal chemistry, due to its potential biological activities, such as anti-inflammatory and anticancer properties. Its structural features allow it to interact with biological targets, making it a subject of research in drug development. Additionally, the compound can undergo various chemical reactions, including acylation and substitution, which can be utilized to synthesize derivatives with enhanced properties or activities.

Formula: C₉H₈N₂O

InChI: InChI=1S/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12)

InChI key: InChIKey=GQMYQEAXTITUAE-UHFFFAOYSA-N

SMILES: C(N)(=O)C=1C=C2C(=CC1)NC=C2

Synonyms:

• 5-(Aminocarbonyl)-1H-indole
• 5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole
• 5-Carbamoylindole
• Indole-5-carboxamide
• Sd-169
• 1H-Indole-5-carboxamide

1H-indole-5-carboxamide

CAS: 1670-87-7

Formula: C₉H₈N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 160.1726

Ref: IN-DA003EEJ

1H-Indole-5-Carboxamide

CAS: 1670-87-7

1H-Indole-5-Carboxamide

Purity: 98%

Molecular weight: 160.17g/mol

Ref: 54-OR1027882

SD-169

CAS: 1670-87-7

SD-169

Purity: ≥98%

Molecular weight: 160.17g/mol

Ref: 54-BUP11855

SD-169

CAS: 1670-87-7

Ref: 7W-GW8497

SD-169

CAS: 1670-87-7

SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.

Formula: C₉H₈N₂O

Purity: 98.6%

Color and Shape: Solid

Molecular weight: 160.17

Ref: TM-T7661

1H-Indole-5-carboxamide

CAS: 1670-87-7

Formula: C₉H₈N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 160.176

Ref: 10-F050330

1H-Indole-5-carboxamide

Controlled Product

CAS: 1670-87-7

Applications 1H-Indole-5-carboxamide (SD-169) is a p38α MAPK-selective inhibitor. 1H-Indole-5-carboxamide (SD-169) prevents the development and progression of diabetes in nonobese diabetic (NOD) mice by inhibiting T cell infiltration and activation.
References Medicherla, S. et al.: J. Pharmacol. Exp. Therap., 318, 99 (2006);

Formula: C₉H₈N₂O

Color and Shape: Neat

Molecular weight: 160.17

Ref: TR-I615500