CAS 16711-91-4

11-monoketofusidic acid

Description:

11-Monoketofusidic acid, identified by its CAS number 16711-91-4, is a chemical compound that belongs to the class of fusidic acid derivatives. It is characterized by its structure, which includes a steroid-like framework with a ketone functional group at the 11th position. This compound exhibits antibacterial properties, primarily effective against Gram-positive bacteria, making it relevant in pharmaceutical applications, particularly in the treatment of skin infections. The mechanism of action typically involves the inhibition of bacterial protein synthesis, which is crucial for bacterial growth and reproduction. Additionally, 11-monoketofusidic acid may possess anti-inflammatory properties, contributing to its therapeutic potential. Its solubility and stability in various solvents can influence its bioavailability and efficacy in medicinal formulations. As with many chemical substances, safety and handling precautions are essential due to potential toxicity or side effects associated with its use. Overall, 11-monoketofusidic acid represents a significant compound in the field of medicinal chemistry, particularly in the development of antibacterial agents.

Formula: C₃₁H₄₆O₆

InChI: InChI=1/C31H46O6/c1-7-26(34)37-25-16-31(6)21-12-11-20-18(4)23(32)13-14-30(20,5)28(21)24(33)15-22(31)27(25)19(29(35)36)10-8-9-17(2)3/h9,18,20-23,25,28,32H,7-8,10-16H2,1-6H3,(H,35,36)/b27-19-/t18-,20?,21-,22-,23+,25-,28-,30-,31+/m0/s1

Synonyms:

• 11-Ketofusidic acid
• 29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3-hydroxy-11-oxo-, (3alpha,4alpha,8alpha,9beta,13alpha,14beta,16beta,17Z)-
• (2Z)-2-[(3alpha,4alpha,8alpha,9beta,13alpha,14beta,16beta,17Z)-3-hydroxy-4,10,14-trimethyl-11-oxo-16-(propanoyloxy)gonan-17-ylidene]-6-methylhept-5-enoic acid
• 11-Monoketofusidic acid
• Fusidic Acid EP Impurity H (Sodium Fusidate EP Impurity H/ 11-Didehydro Fusidic Acid/ 11-Keto Fusidic Acid)
• Sodium Fusidate EP Impurity H
• Fusidic Acid EP Impurity H (11-Keto FusidicAcid)
• 11-Ketofusidinsaeure
• 29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3-hydroxy-11-oxo-, (3α,4α,8α,9β,13α,14β,16β,17Z)-
• (Z)-2-((3R,4S,5S,8S,9S,10S,13R,14S,16S)-16-acetoxy-3-hydroxy-4,8,10,14-tetramethyl-11-oxohexadecahydro-17H-cyclopenta[a]phenanthren-17-ylidene)-6-methylhept-5-enoic acid
• (3α,4α,8α,9β,13α,14β,16β,17Z)-16-(Acetyloxy)-3-hydroxy-11-oxo-
• Fusidic Acid EP Impurity H
• 11-Keto Fusidic Acid
• Fusidic Acid Impurity H
• Sodium Fusidate Impurity 8（Sodium Fusidate EP Impurity H）
• Fucidic acid EP impurity H
• Fusidic Acid Impurity H(EP)

29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3-hydroxy-11-oxo-, (3α,4α,8α,9β,13α,14β,16β,17Z)-

CAS: 16711-91-4

Formula: C₃₁H₄₆O₆

Color and Shape: Solid

Molecular weight: 514.6933

Ref: IN-DA001X5J

Fusidic Acid EP Impurity H (11-Keto Fusidic Acid)

CAS: 16711-91-4

Formula: C₃₁H₄₆O₆

Color and Shape: White To Off-White Solid

Molecular weight: 514.70

Ref: 4Z-F-543

11-Keto fusidic acid

CAS: 16711-91-4

11-Keto fusidic acid exhibits potent antibacterial efficacy against Staphylococcus aureus, demonstrating a minimum inhibitory concentration (MIC) of 0.078 μg/mL

Formula: C₃₁H₄₆O₆

Color and Shape: Solid

Molecular weight: 514.69

Ref: TM-T75445

11-Keto Fusidic Acid

CAS: 16711-91-4

Impurity Fusidic Acid EP Impurity H
Applications 11-Keto Fusidic Acid (Fusidic Acid EP Impurity H) is a metabolite of Fusidic Acid.
References Godtfredsen, W.O., et al.: J. Med. Chem., 9, 15 (1966), Perry, M.J., et al.: J. Antibiot., 36, 1659 (1983),

Formula: C₃₁H₄₆O₆

Color and Shape: Off White Solid

Molecular weight: 514.69

Ref: TR-K188990

Fusidic Acid EP Impurity H

CAS: 16711-91-4

Formula: C₃₁H₄₆O₆

Molecular weight: 514.7

Ref: ST-EA-CP-F45008

11-Keto fusidic acid

CAS: 16711-91-4

Fusidic acid is a hydrophilic antibiotic that is structurally related to penicillin. It has a cavity that interacts with γ-cyclodextrin, which can be used for its monitoring and stoichiometry. Fusidic acid has hydroxyl groups that are located on the 7th and 8th positions of the fusidate ring. This antibiotic has been shown to have stability constants in a range of 10-10 M. Fusidic acid also has two electrophoretically distinct forms, depending on the pH of the solution. The form at pH 10 is called fusidane, while the form at pH 5 is called fusidate.

Formula: C₃₁H₄₆O₆

Purity: Min. 95%

Molecular weight: 514.69 g/mol

Ref: 3D-FK24773