CAS 167256-08-8

Enrasentan

Description:

Enrasentan is a chemical compound classified as an endothelin receptor antagonist, specifically targeting the endothelin-1 receptor. It is primarily investigated for its potential therapeutic applications in conditions such as hypertension and heart failure. The molecular structure of Enrasentan features a complex arrangement that allows it to effectively bind to the endothelin receptors, thereby inhibiting the action of endothelin-1, a potent vasoconstrictor. This inhibition can lead to vasodilation and a subsequent reduction in blood pressure. Enrasentan is characterized by its moderate solubility in organic solvents and relatively low solubility in water, which can influence its bioavailability and pharmacokinetics. The compound has undergone various clinical trials to assess its efficacy and safety profile, although its development status may vary. As with many pharmacological agents, understanding its mechanism of action, side effects, and interactions with other medications is crucial for its therapeutic use.

Formula: C₂₉H₃₀O₈

InChI: InChI=1S/C29H30O8/c1-3-11-34-19-6-7-20-22(14-19)27(21-8-5-18(33-2)15-24(21)35-12-10-30)28(29(31)32)26(20)17-4-9-23-25(13-17)37-16-36-23/h4-9,13-15,26-28,30H,3,10-12,16H2,1-2H3,(H,31,32)/t26-,27+,28+/m0/s1

InChI key: InChIKey=GLCKXJLCYIJMRB-UPRLRBBYSA-N

SMILES: C(O)(=O)[C@H]1[C@@H](C=2C([C@@H]1C=3C=C4C(=CC3)OCO4)=CC=C(OCCC)C2)C5=C(OCCO)C=C(OC)C=C5

Synonyms:

• (1S,2R,3S)-1-(1,3-Benzodioxol-5-yl)-2,3-dihydro-3-[2-(2-hydroxyethoxy)-4-methoxyphenyl]-5-propoxy-1H-indene-2-carboxylic acid
• Enrasentan
• 1H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-2,3-dihydro-3-[2-(2-hydroxyethoxy)-4-methoxyphenyl]-5-propoxy-, (1S,2R,3S)-
• SB 217242
• 1H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-2,3-dihydro-3-[2-(2-hydroxyethoxy)-4-methoxyphenyl]-5-propoxy-, [1S-(1α,2β,3α)]-

Enrasentan

CAS: 167256-08-8

Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure and protects myocardial function.

Formula: C₂₉H₃₀O₈

Purity: 97.9% - 98.39%

Color and Shape: Solid

Molecular weight: 506.54

Ref: TM-T31640

Enrasentan

CAS: 167256-08-8

Enrasentan

Purity: ≥95%

Molecular weight: 506.54g/mol

Ref: 54-BUP01875