CAS 167354-41-8: Zosuquidar

Description: Zosuquidar, with the CAS number 167354-41-8, is a small molecule that functions primarily as a P-glycoprotein inhibitor. It is notable for its role in enhancing the efficacy of chemotherapeutic agents by preventing the efflux of these drugs from cancer cells, thereby increasing their intracellular concentrations. Zosuquidar is characterized by its ability to cross the blood-brain barrier, which is significant for treating central nervous system malignancies. The compound has a relatively low solubility in water, which can affect its bioavailability and pharmacokinetics. Its chemical structure includes multiple aromatic rings and nitrogen-containing groups, contributing to its pharmacological properties. Zosuquidar has been investigated in various clinical settings, particularly in combination therapies for cancers resistant to standard treatments. Overall, its mechanism of action and pharmacological profile make it a valuable candidate in cancer therapeutics, particularly in overcoming multidrug resistance.

Formula: C₃₂H₃₁F₂N₃O₂

InChI: InChI=1S/C32H31F2N3O2/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27/h1-14,21,29-31,38H,15-20H2/t21-,29-,30+,31-/m1/s1

InChI key: InChIKey=IHOVFYSQUDPMCN-DBEBIPAYSA-N

SMILES: FC1(F)C2C=3C=CC=CC3C(C=4C=CC=CC4C21)N5CCN(CC5)CC(O)COC6=CC=CC7=NC=CC=C76

Synonyms:

• (2R)-1-{4-[(1aR,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c][7]annulen-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol trihydrochloride
• (2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol
• (αR)-4-[(1Aα,6α,10bα)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol
• 1-Piperazineethanol, 4-[(1aα,6α,10bα)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-, (αR)-
• Lsn 335979
• Zosuquidar

(2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol

CAS: 167354-41-8

• Formula: C₃₂H₃₁F₂N₃O₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 527.6042

Zosuquidar

CAS: 167354-41-8

Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.

• Formula: C₃₂H₃₁F₂N₃O₂
• Color and Shape: Solid
• Molecular weight: 527.6

Zosuquidar

CAS: 167354-41-8

Zosuquidar is an ATP-binding cassette transporter (ABC) inhibitor that has been shown to inhibit the …

• Formula: C₃₂H₃₁F₂N₃O₂
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 527.6 g/mol