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CAS 167354-41-8

:

Zosuquidar

Description:
Zosuquidar, with the CAS number 167354-41-8, is a small molecule that functions primarily as a P-glycoprotein inhibitor. It is notable for its role in enhancing the efficacy of chemotherapeutic agents by preventing the efflux of these drugs from cancer cells, thereby increasing their intracellular concentrations. Zosuquidar is characterized by its ability to cross the blood-brain barrier, which is significant for treating central nervous system malignancies. The compound has a relatively low solubility in water, which can affect its bioavailability and pharmacokinetics. Its chemical structure includes multiple aromatic rings and nitrogen-containing groups, contributing to its pharmacological properties. Zosuquidar has been investigated in various clinical settings, particularly in combination therapies for cancers resistant to standard treatments. Overall, its mechanism of action and pharmacological profile make it a valuable candidate in cancer therapeutics, particularly in overcoming multidrug resistance.
Formula:C32H31F2N3O2
InChI:InChI=1/C32H31F2N3O2/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27/h1-14,21,29-31,38H,15-20H2/t21-,29-,30+,31-/m1/s1
InChI key:InChIKey=IHOVFYSQUDPMCN-DBEBIPAYSA-N
SMILES:FC1(F)[C@]2([C@@]1(C=3C([C@@H](C=4C2=CC=CC4)N5CCN(C[C@H](COC=6C7=C(C=CC6)N=CC=C7)O)CC5)=CC=CC3)[H])[H]
Synonyms:
  • (2R)-1-{4-[(1aR,10bS)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c][7]annulen-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol trihydrochloride
  • (2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol
  • (αR)-4-[(1Aα,6α,10bα)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol
  • 1-Piperazineethanol, 4-[(1aα,6α,10bα)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-, (αR)-
  • Lsn 335979
  • Zosuquidar
  • Zosuquidar [inn]
  • (2R)-Anti-5-[3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy]quinoline hydrochloride
  • LY335979; LY 335979; LY-335979
  • CS-251
  • See more synonyms
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