Clofarabine-5'-triphosphate is a nucleotide analog and an active metabolite of clofarabine, which is primarily used in the treatment of certain types of leukemia. As a triphosphate, it features a ribose sugar linked to a purine base, specifically adenine, and three phosphate groups. This structure allows it to mimic natural nucleotides, enabling it to interfere with DNA synthesis and repair processes. Clofarabine-5'-triphosphate is characterized by its ability to inhibit DNA polymerases, leading to cytotoxic effects in rapidly dividing cells, which is particularly beneficial in cancer therapy. Its solubility in aqueous solutions and stability under physiological conditions make it suitable for therapeutic applications. Additionally, the compound's mechanism of action involves incorporation into DNA strands, resulting in chain termination and apoptosis of malignant cells. Overall, Clofarabine-5'-triphosphate exemplifies the strategic design of chemotherapeutic agents aimed at disrupting the proliferation of cancer cells.

Clofarabine-5'-triphosphate

167620-89-5: Clofarabine-5'-triphosphate is a nucleotide analog and an active metabolite of clofarabine, which is primarily used in the treatment of certain types of leukemia. As a triphosphate, it features a ribose sugar linked to a purine base, specifically adenine, and three phosphate groups. This structure allows it to mimic natural nucleotides, enabling it to interfere with DNA synthesis and repair processes. Clofarabine-5'-triphosphate is characterized by its ability to inhibit DNA polymerases, leading to cytotoxic effects in rapidly dividing cells, which is particularly beneficial in cancer therapy. Its solubility in aqueous solutions and stability under physiological conditions make it suitable for therapeutic applications. Additionally, the compound's mechanism of action involves incorporation into DNA strands, resulting in chain termination and apoptosis of malignant cells. Overall, Clofarabine-5'-triphosphate exemplifies the strategic design of chemotherapeutic agents aimed at disrupting the proliferation of cancer cells.

<p>Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.</p>

CAS 167620-89-5

Clofarabine-5'-triphosphate

Clofarabine-5'-diphosphate

Ref: TM-T203181