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CAS 16783-97-4

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3-Formyl-25-desacetyl Rifamycin

Description:
3-Formyl-25-desacetyl Rifamycin, identified by its CAS number 16783-97-4, is a derivative of the rifamycin class of antibiotics, which are primarily known for their efficacy against bacterial infections, particularly tuberculosis. This compound features a formyl group at the 3-position and lacks the acetyl group at the 25-position, distinguishing it from other rifamycins. Its structure contributes to its biological activity, as rifamycins generally inhibit bacterial RNA synthesis by binding to the DNA-dependent RNA polymerase. The compound is characterized by its complex macrocyclic structure, which includes multiple rings and functional groups that enhance its pharmacological properties. In terms of solubility, rifamycins typically exhibit moderate solubility in organic solvents but limited solubility in water, which can affect their bioavailability. Additionally, 3-Formyl-25-desacetyl Rifamycin may exhibit varying degrees of stability under different pH conditions and temperatures, influencing its storage and handling. Overall, this compound represents a significant area of study in medicinal chemistry, particularly in the development of new antimicrobial agents.
Formula:C36H45NO12
InChI:InChI=1/C36H45NO12/c1-15-10-9-11-16(2)35(46)37-26-21(14-38)31(43)23-24(32(26)44)30(42)20(6)33-25(23)34(45)36(7,49-33)48-13-12-22(47-8)17(3)28(40)19(5)29(41)18(4)27(15)39/h9-15,17-19,22,27-29,39-44H,1-8H3,(H,37,46)/b10-9-,13-12+,16-11+
Synonyms:
  • 1,2-Dihydro-5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-8-carboxaldehyde
  • 25-O-Deacetyl-3-formylrifamycin
  • Nsc 14563
  • Nsc 145635
  • (24E)-5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-8-carbaldehyde
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