2'-C-Methyl-2-thiouridine is a modified nucleoside that features a methyl group at the 2' position of the ribose sugar and a thiol group in place of the oxygen at the 2 position of the uracil base. This modification enhances the stability of the nucleoside against enzymatic degradation, making it of interest in various biochemical applications, including RNA research and therapeutic development. The presence of the methyl group can influence the nucleoside's hydrogen bonding and base pairing properties, potentially affecting its incorporation into RNA strands. Additionally, the thiol group can participate in redox reactions, providing unique chemical reactivity compared to standard nucleosides. 2'-C-Methyl-2-thiouridine is often studied for its role in the synthesis of modified RNA molecules and its potential use in antiviral therapies, particularly against RNA viruses. Its unique structural characteristics contribute to its functionality in biological systems and its utility in synthetic biology and medicinal chemistry.

2'--C-Methyl-2-thiouridine

1678507-60-2: 2'-C-Methyl-2-thiouridine is a modified nucleoside that features a methyl group at the 2' position of the ribose sugar and a thiol group in place of the oxygen at the 2 position of the uracil base. This modification enhances the stability of the nucleoside against enzymatic degradation, making it of interest in various biochemical applications, including RNA research and therapeutic development. The presence of the methyl group can influence the nucleoside's hydrogen bonding and base pairing properties, potentially affecting its incorporation into RNA strands. Additionally, the thiol group can participate in redox reactions, providing unique chemical reactivity compared to standard nucleosides. 2'-C-Methyl-2-thiouridine is often studied for its role in the synthesis of modified RNA molecules and its potential use in antiviral therapies, particularly against RNA viruses. Its unique structural characteristics contribute to its functionality in biological systems and its utility in synthetic biology and medicinal chemistry.

2'-C-Methyl-2-thiouridine is a Nucleoside Derivative - Thio-nucleoside, 2'-Modified nucleoside.

2'-C-Methyl-2-thiouridine

<p>2’C-Methyl-2-thiouridine is a novel nucleoside phosphoramidite that has been synthesized to serve as an activator for DNA polymerases. 2’C-Methyl-2-thiouridine is a potent antiviral agent that inhibits the replication of the hepatitis C virus in vitro. It also has antiproliferative effects against certain cancer cells and can be used as an anticancer drug. 2’C-Methyl-2-thiouridine contains a methylated thiol group, which confers a high degree of resistance to degradation by thiols, including glutathione (GSH). This compound is stable to hydrolysis and may be used in the synthesis of deoxyribonucleosides or monophosphate nucleotides.</p>

CAS 1678507-60-2

2'--C-Methyl-2-thiouridine

2'-C-Methyl-2-thiouridine

Ref: TM-TNU0135

2’C-Methyl-2-thiouridine

Ref: 3D-NM162868