CAS 1680184-59-1

(2Z)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide

Description:

The chemical substance with the name "(2Z)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide" and CAS number "1680184-59-1" is a complex organic compound characterized by its unique structural features. It contains a quinazoline core, which is a bicyclic structure known for its biological activity, particularly in medicinal chemistry. The presence of a chloro and a fluoro substituent on the phenyl ring enhances its pharmacological properties. Additionally, the compound features a dimethylamino group, which can influence its solubility and interaction with biological targets. The tetrahydrofuran moiety contributes to the compound's three-dimensional conformation, potentially affecting its binding affinity to specific receptors or enzymes. Overall, this compound is likely to exhibit significant biological activity, making it of interest in drug discovery and development, particularly in the context of targeting specific diseases or conditions. Its detailed characterization would require further studies, including spectroscopic analysis and biological assays.

Formula: C₂₄H₂₅ClFN₅O₃

InChI: InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3-/t16-/m0/s1

InChI key: InChIKey=ULXXDDBFHOBEHA-QGZUEGPWSA-N

SMILES: N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C\CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

Synonyms:

• (2Z)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
• 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2Z)-

(2Z)-Afatinib

CAS: 1680184-59-1

Afatinib is a potent, selective, and ATP-competitive inhibitor of EGFR. It blocks the phosphorylation of tyrosine residues on the extracellular domain of EGFR, thereby inhibiting receptor activation and causing inhibition of tumor cell proliferation in vitro and in vivo. Afatinib has been used as a research tool to study the function and regulation of EGFR signaling pathways. Afatinib has also been shown to block activation of the human transient receptor potential channel TRPM8 by menthol, which may be due to its ability to inhibit protein interactions with the channel.

Formula: C₂₄H₂₅ClFN₅O₃

Purity: Min. 95%

Molecular weight: 485.9 g/mol

Ref: 3D-FSC18459

(2Z)-Afatinib

Controlled Product

CAS: 1680184-59-1

Formula: C₂₄H₂₅ClFN₅O₃

Color and Shape: Neat

Molecular weight: 485.94

Ref: TR-A355305

Afatinib Impurity D

CAS: 1680184-59-1

Formula: C₂₄H₂₅ClFN₅O₃

Molecular weight: 485.94

Ref: ST-EA-CP-A50004

(Z)-Afatinib ((R)-BIBW 2992)

CAS: 1680184-59-1

Formula: C₂₄H₂₅ClFN₅O₃

Molecular weight: 485.95

Ref: 4Z-A-111007