CAS 1680193-80-9

[4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-1H-1,2,4-triazol-1-ylmethanone

Description:

The chemical substance with the name "[4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-1H-1,2,4-triazol-1-ylmethanone" and CAS number "1680193-80-9" is a complex organic compound characterized by its unique structural features, including a triazole ring and a piperidine moiety. The presence of the chloro substituent and the benzo-cycloheptapyridine framework contributes to its potential biological activity. This compound may exhibit properties relevant to medicinal chemistry, particularly in the development of pharmaceuticals targeting various biological pathways. Its intricate structure suggests potential interactions with biological macromolecules, making it a candidate for further investigation in drug discovery. Additionally, the compound's solubility, stability, and reactivity would be essential considerations in its application and formulation. As with many synthetic organic compounds, understanding its physicochemical properties, such as melting point, boiling point, and spectral characteristics, would be crucial for its characterization and practical use in research or therapeutic contexts.

Formula: C₂₂H₂₀ClN₅O

InChI: InChI=1S/C22H20ClN5O/c23-18-5-6-19-17(12-18)4-3-16-2-1-9-25-21(16)20(19)15-7-10-27(11-8-15)22(29)28-14-24-13-26-28/h1-2,5-6,9,12-14H,3-4,7-8,10-11H2

InChI key: InChIKey=GAVZCGTYRWKKDV-UHFFFAOYSA-N

SMILES: ClC=1C=C2C(C(C=3C(CC2)=CC=CN3)=C4CCN(C(=O)N5C=NC=N5)CC4)=CC1

Synonyms:

• Methanone, [4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-1H-1,2,4-triazol-1-yl-
• JZP 361
• [4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-1H-1,2,4-triazol-1-ylmethanone

JZP-361

CAS: 1680193-80-9

JZP-361

Purity: ≥98%

Molecular weight: 405.88g/mol

Ref: 54-BUP06411

JZP 361

CAS: 1680193-80-9

JZP 361 is a peptide fragment of the human protein, thrombospondin-1. It is a potent inhibitor of TGF-β1 and IL-1β signaling, which are both implicated in inflammatory responses. JZP 361 has been shown to inhibit IL-6 production by macrophages and to activate neutrophils by increasing the expression of CD11b and CD18 proteins. These effects may be mediated through interactions with TGF-β receptors, IL-1 receptors, or integrins. The antibody against JZP 361 has been shown to bind specifically to the peptide fragment at pH 7.4 in a range of 1–500 nM concentration.

Formula: C₂₂H₂₀ClN₅O

Purity: Min. 95%

Molecular weight: 405.9 g/mol

Ref: 3D-FSC19380

JZP-361

CAS: 1680193-80-9

JZP-361: selective MAGL inhibitor (IC50 = 46 nM); weaker on FAAH, hABHD6; anti-histamine; for asthma research.

Formula: C₂₂H₂₀ClN₅O

Purity: 99.82%

Color and Shape: Solid

Molecular weight: 405.88

Ref: TM-T27703