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CAS 16803-92-2

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4-AMINO-N-(4-CHLORO-PHENYL)-BENZENESULFONAMIDE

Description:
4-Amino-N-(4-chloro-phenyl)-benzenesulfonamide, commonly known as sulfamethoxazole, is a sulfonamide antibiotic characterized by its structural features, which include an amino group and a sulfonamide functional group. This compound is typically a white to off-white crystalline solid, exhibiting moderate solubility in water and organic solvents. It has a molecular formula that reflects its complex structure, incorporating both aromatic and aliphatic components. The presence of the chloro substituent on the phenyl ring enhances its antibacterial activity by inhibiting bacterial dihydropteroate synthase, a key enzyme in folate synthesis. This compound is often used in combination with trimethoprim to treat a variety of bacterial infections, particularly urinary tract infections and respiratory tract infections. Its pharmacokinetics involve oral absorption, with a half-life that allows for effective dosing regimens. However, it may also present side effects, including allergic reactions and gastrointestinal disturbances, necessitating careful monitoring during therapeutic use.
Formula:C12H11ClN2O2S
InChI:InChI=1/C12H11ClN2O2S/c13-9-1-5-11(6-2-9)15-18(16,17)12-7-3-10(14)4-8-12/h1-8,15H,14H2
SMILES:c1cc(ccc1Cl)NS(=O)(=O)c1ccc(cc1)N
Synonyms:
  • Akos B014350
  • Art-Chem-Bb B014350
  • Timtec-Bb Sbb009347
  • 4-amino-N-(4-chlorophenyl)benzene-1-sulfonamide
  • 4-AMINO-N-(4-CHLORO-PHENYL)-BENZENESULFONAMIDE
  • BenzenesulfonaMide,4-aMino-N-(4-chlorophenyl)-
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