CAS 1681017-83-3
:Venadaparib
Description:
Venadaparib is a small molecule inhibitor primarily designed for the treatment of cancer, particularly targeting poly(ADP-ribose) polymerase (PARP) enzymes, which play a crucial role in DNA repair mechanisms. By inhibiting PARP, Venadaparib can enhance the effectiveness of certain chemotherapeutic agents and may induce synthetic lethality in cancer cells with specific genetic mutations, such as BRCA1 or BRCA2 deficiencies. The compound is characterized by its ability to interfere with the repair of single-strand breaks in DNA, leading to increased cell death in tumors that rely on PARP for survival. Venadaparib is typically administered orally and has undergone various clinical trials to assess its efficacy and safety profile. Its chemical structure includes specific functional groups that contribute to its biological activity, and it is classified under the category of targeted therapies in oncology. As with many investigational drugs, ongoing research continues to explore its potential applications and combinations with other therapeutic agents.
Formula:C23H23FN4O2
Synonyms:- Venadaparib(IDX-1197)
- NOV140101
- IDX-1197/Venadaparib
- Venadaparib
- 1(2H)-Phthalazinone, 4-[[3-[[3-[(cyclopropylamino)methyl]-1-azetidinyl]carbonyl]-4-fluorophenyl]methyl]-
- IDX-1197
- inhibit,PARP,Venadaparib,IDX1197,Inhibitor,solid,IDX 1197,tumors,anticancer,poly ADP ribose polymerase
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Found 2 products.
Venadaparib
CAS:<p>Venadaparib, a PARP inhibitor (IC50: 1.4/1.0 nM for PARP1/2), is orally active, selective, not affecting PARP-5, used in tumor studies.</p>Formula:C23H23FN4O2Purity:99.86%Color and Shape:SolidMolecular weight:406.45
