CAS 168110-44-9

Micafungin FR-179642

Description:

Micafungin, also known by its developmental code FR-179642, is an echinocandin antifungal agent primarily used in the treatment of invasive fungal infections, particularly those caused by Candida and Aspergillus species. It works by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the fungal cell wall, thereby compromising the structural integrity of the fungus and leading to cell lysis. Micafungin is typically administered intravenously and is characterized by its broad-spectrum antifungal activity, low toxicity, and favorable pharmacokinetic profile. It is often utilized in immunocompromised patients, such as those undergoing chemotherapy or organ transplantation, where the risk of fungal infections is heightened. The substance is generally well-tolerated, with common side effects including infusion-related reactions and mild liver enzyme elevations. Its stability and solubility in aqueous solutions make it suitable for clinical use, and it is classified under the echinocandin class of antifungals, which are derived from fungal sources.

Formula: C₃₅H₅₂N₈O₂₀S

Synonyms:

• Micafungin FR-179642 impurity (acid)
• Micafungin Nucleus
• FR-179642
• MFA/CBR03-2
• FR179642, CMICA
• Micafungin FR-179642
• Micafungin FR-179642 IMpurity
• Micafungin Impurity FR-179642
• Micafungin Impurity 10
• Micafungin Sodium N-1 intermediate
• 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0
• FR 179642 (~90%)
• N-1 Micafungin Sodium
• FRAN
• Pneumocandin A0, 1-[(4R,5R)-4,5-dihydroxy-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]-

FR179642

CAS: 168110-44-9

Formula: C₃₅H₅₂N₈O₂₀S

Purity: 98%

Color and Shape: Solid

Molecular weight: 936.8940

Ref: IN-DA001XST

FR179642

CAS: 168110-44-9

FR179642

Purity: ≥95%

Molecular weight: 936.89g/mol

Ref: 54-OR1007328

Micafungin Impurity FR-179642

CAS: 168110-44-9

Formula: C₃₅H₅₂N₈O₂₀S

Color and Shape: White To Off-White Solid

Molecular weight: 936.90

Ref: 4Z-PM-127011

FR179642

CAS: 168110-44-9

FR179642 is a key intermediate for making Micafungin, a drug from the echinocandin class.

Formula: C₃₅H₅₂N₈O₂₀S

Color and Shape: Solid

Molecular weight: 936.9

Ref: TM-T39148

FR179642

CAS: 168110-44-9

Molecular weight: 936.9

Ref: 10-F986958

FR 179642

Controlled Product

CAS: 168110-44-9

Applications FR 179642 is an impurity of Micafungin (M342350), a lipopeptide compound that acts as an antifungal agent with activity against Aspergillus and Candida species.
References Denning, D., et al.: J. Infection, 53, 337 (2006); Queiroz-Telles, F., et al.: Pediatr. Infect. Dis. J., 27, 820 (2008)

Formula: C₃₅H₅₂N₈O₂₀S

Color and Shape: Neat

Molecular weight: 936.89

Ref: TR-F763400

Micafungin Nucleus

CAS: 168110-44-9

Formula: C₃₅H₅₂N₈O₂₀S

Molecular weight: 936.9

Ref: ST-EA-CP-M94011

Micafungin FR-179642 impurity (acid)

CAS: 168110-44-9

Micafungin is an antifungal drug that inhibits the synthesis of ergosterol, a vital component of fungal cell membranes. It is a cyclic peptide with a lipophilic fatty acid chain that has been modified to allow penetration into cells. Micafungin is active against Candida and Aspergillus species and has shown activity against some strains of Cryptococcus neoformans. The MIC (minimum inhibitory concentration) for this drug ranges from 0.06 to 1 microgram/mL, depending on the bacterial strain being tested. Micafungin FR-179642 impurity (acid) is an impurity in micafungin that can be present as trace amounts in the final product and may contribute to hemolytic activity. This impurity is formed by hydrolysis during the synthesis process.

Formula: C₃₅H₅₂N₈O₂₀S

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 936.9 g/mol

Ref: 3D-FF33138