CAS 168135-77-1

Fmoc-Tyr(malonyl-di-OtBu)-OH

Description:

Fmoc-Tyr(malonyl-di-OtBu)-OH is a chemical compound that belongs to the class of amino acids, specifically a derivative of tyrosine. It features a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group, which is commonly used in peptide synthesis to protect the amino group of the amino acid. The compound also contains a malonyl group and two tert-butyl (OtBu) ester groups, which enhance its stability and solubility. The presence of these functional groups suggests that it may be utilized in the synthesis of peptides or other complex organic molecules, particularly in solid-phase peptide synthesis. The malonyl moiety can provide additional reactivity, potentially allowing for further modifications or coupling reactions. As with many synthetic intermediates, the compound is likely to be sensitive to moisture and should be handled under anhydrous conditions. Overall, Fmoc-Tyr(malonyl-di-OtBu)-OH is characterized by its protective groups, which facilitate its use in organic synthesis while maintaining the integrity of the tyrosine residue.

Formula: C₃₅H₃₉NO₉

Synonyms:

• (2S)-3-(4-{[1,3-bis(tert-butoxy)-1,3-dioxopropan-2-yl]oxy}phenyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
• N-α-(9-Fluorenylmethoxycarbonyl)-O-[di(t-butyl)malonyl]-L-tyrosine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tyrosine O-malonic acid di(tert-butyl) ester
• Propanedioic acid, 2-[4-[(2S)-2-carboxy-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]phenoxy]-, 1,3-bis(1,1-dimethylethyl) ester
• FMOC-TYR(MALONYL-DI-OTBU)-OH USP/EP/BP
• FMOC-TYR[CH(COOTBU) 2]-OH
• FMOC-TYROSINE(MALONYL-DI-OTBU)-OH
• O-(1,3-Di-tert-butoxy-1,3-dioxopropan-2-yl)-Fmoc-L-tyrosine
• N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-DI-T-BUTYL-MALONYL-L-TYROSINE
• FMOC-TYR(MALONYL-DI-OTBU)-OH

Propanedioic acid, 2-[4-[(2S)-2-carboxy-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]phenoxy]-, 1,3-bis(1,1-dimethylethyl) ester

CAS: 168135-77-1

Formula: C₃₅H₃₉NO₉

Purity: 97%

Molecular weight: 617.6855

Ref: IN-DA001XUC

Fmoc-Tyr(malonyl-di-OtBu)-OH

CAS: 168135-77-1

The phosphotyrosine-mimicking amino acid Fmoc-Tyr(malonyl-di-OtBu)-OH can be used as a building block for the synthesis of cell-permeable protein tyrosine phosphatase (PTP) inhibitors. The effect of a malonyl-tyrosine containing peptide on PTP 1B catalyzed insulin receptor dephosphorylation has been examined and it was shown that this peptide inhibited PTP 1B 20 times more potently than the corresponding phosphotyrosine containing peptide.

Formula: C₃₅H₃₉NO₉

Purity: > 95%

Color and Shape: White Powder

Molecular weight: 617.7

Ref: 01-4026574