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CAS 168147-41-9

:

Agitoxin 2 (9CI)

Description:
Agitoxin 2 (9CI), with the CAS number 168147-41-9, is a potent neurotoxin derived from the venom of the Central American spider Agelenopsis aperta. This compound is known for its ability to selectively block voltage-gated sodium channels, which are crucial for the propagation of action potentials in neurons. As a result, Agitoxin 2 can disrupt normal neuronal signaling, leading to paralysis or other neurological effects. The substance is characterized by its high specificity for certain sodium channel subtypes, making it a valuable tool in neuropharmacology for studying ion channel function and neuronal excitability. In addition to its research applications, the toxicological properties of Agitoxin 2 raise concerns regarding its potential effects on human health and the environment. Its stability under various conditions and the mechanisms of its action are subjects of ongoing research, contributing to a deeper understanding of neurotoxic compounds and their interactions with biological systems.
Formula:C169H278N54O48S8
Synonyms:
  • 23: PN:WO2008088422 FIGURE: 7A claimed protein
  • 24: PN: WO2006116156 SEQID: 23 claimedprotein
  • L-Lysine,glycyl-L-valyl-L-prolyl-L-isoleucyl-L-asparaginyl-L-valyl-L-seryl-L-cysteinyl-L-threonylglycyl-L-seryl-L-prolyl-L-glutaminyl-L-cysteinyl-L-isoleucyl-L-lysyl-L-prolyl-L-cysteinyl-L-lysyl-L-a-aspartyl-L-alanylglycyl-L-methionyl-L-arginyl-L-phenylalanylglycyl-L-lysyl-L-cysteinyl-L-methionyl-L-asparaginyl-L-arginyl-L-lysyl-L-cysteinyl-L-histidyl-L-cysteinyl-L-threonyl-L-prolyl-,cyclic (8® 28),(14® 33),(18® 35)-tris(disulfide)
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Found 2 products.
  • Agitoxin-2
    Targetmol
    + Info

    Agitoxin-2

    CAS:
    Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).
    Formula:C169H278N54O48S8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4090.87

    Ref: TM-TP2089

  • Agitoxin 2
    Biosynth
    + Info

    Agitoxin 2

    CAS:
    <p>Agitoxin 2 is a peptide with high resistance to the proteolytic activity of various enzymes, including trypsin, pepsin, and chymotrypsin. Agitoxin 2 is a structural analogue of the acetylcholine receptor agonist carbamylcholine. It binds to the alpha subunit of the nicotinic acetylcholine receptor and inhibits its activation by acetylcholine. Agitoxin 2 has been shown to be effective in animal models for autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. Agitoxin 2 also has an analgesic effect in animals. The molecule's ability to inhibit the release of inflammatory cytokines may be due to its inhibition of transcription-polymerase chain reaction (PCR).</p>
    Formula:C169H278N54O48S8
    Purity:Min. 95%
    Molecular weight:4,091 g/mol

    Ref: 3D-TGA14741

    1mg
    23,345.00€