CAS 168266-51-1

Vofopitant dihydrochloride

Description:

Vofopitant dihydrochloride is a synthetic compound primarily classified as a neurokinin-1 (NK1) receptor antagonist. It is designed to inhibit the action of substance P, a neuropeptide involved in the transmission of pain and the regulation of various physiological processes, including nausea and vomiting. This compound is often explored for its potential therapeutic applications in managing chemotherapy-induced nausea and vomiting, as well as other conditions where NK1 receptor modulation may be beneficial. Vofopitant dihydrochloride is characterized by its high affinity for NK1 receptors, which contributes to its effectiveness in blocking the emetic response. The dihydrochloride form indicates that the compound is stabilized with two hydrochloride ions, enhancing its solubility in aqueous solutions. As with many pharmaceutical compounds, its safety profile, pharmacokinetics, and potential side effects are subjects of ongoing research to ensure efficacy and minimize adverse reactions in clinical settings.

Formula: C₂₁H₂₅Cl₂F₃N₆O

InChI: InChI=1/C21H23F3N6O.2ClH/c1-31-18-10-9-16(30-20(21(22,23)24)27-28-29-30)12-15(18)13-26-17-8-5-11-25-19(17)14-6-3-2-4-7-14;;/h2-4,6-7,9-10,12,17,19,25-26H,5,8,11,13H2,1H3;2*1H

SMILES: COc1ccc(cc1CNC1CCCNC1c1ccccc1)n1c(C(F)(F)F)nnn1.Cl.Cl

Synonyms:

• 3-Piperidinamine, N-[[2-methoxy-5-[5-(trifluoro-methyl)-1H-tetrazol-1-yl]phenyl]methyl]-2-phenyl-, dihydrochloride, (2S,3S)-
• 3-Piperidinamine, N-[[2-methoxy-5-[5-(trifluoromethyl)-1H-tetrazol-1-yl]phenyl]methyl]-2-phenyl-, dihydrochloride, (2S-cis)-
• Gr 205171A
• GR 205171 Dihydrochloride
• N-{2-methoxy-5-[5-(trifluoromethyl)-1H-tetrazol-1-yl]benzyl}-2-phenylpiperidin-3-amine dihydrochloride

Vofopitant dihydrochloride

CAS: 168266-51-1

Vofopitant dihydrochloride

Purity: ≥98%

Molecular weight: 505.36g/mol

Ref: 54-BUP08796

Vofopitant dihydrochloride

CAS: 168266-51-1

Vofopitant dihydrochloride (GR 205171A) is a tachykinin NK1 receptor antagonist and a potential compound for the treatment of pathologic vomiting.

Formula: C₂₁H₂₅Cl₂F₃N₆O

Purity: 98.99%

Color and Shape: Solid

Molecular weight: 505.36

Ref: TM-T13329L