CAS 168266-90-8: Vofopitant

Description: Vofopitant, with the CAS number 168266-90-8, is a synthetic compound classified as a neurokinin-1 (NK1) receptor antagonist. It is primarily investigated for its potential use in the prevention of nausea and vomiting associated with chemotherapy and postoperative conditions. Vofopitant works by blocking the action of substance P, a neuropeptide involved in the vomiting reflex, thereby helping to mitigate these adverse effects. The compound is characterized by its high affinity for NK1 receptors, which are widely distributed in the central nervous system. In terms of its chemical structure, Vofopitant features a complex arrangement that contributes to its pharmacological activity. It is typically administered orally or intravenously, depending on the clinical context. The safety profile and efficacy of Vofopitant have been subjects of clinical studies, with ongoing research aimed at optimizing its therapeutic applications. As with many pharmacological agents, understanding its pharmacokinetics, potential side effects, and interactions with other medications is crucial for its effective use in clinical settings.

Formula: C₂₁H₂₃F₃N₆O

InChI: InChI=1S/C21H23F3N6O/c1-31-18-10-9-16(30-20(21(22,23)24)27-28-29-30)12-15(18)13-26-17-8-5-11-25-19(17)14-6-3-2-4-7-14/h2-4,6-7,9-10,12,17,19,25-26H,5,8,11,13H2,1H3/t17-,19-/m0/s1

InChI key: InChIKey=XILNRORTJVDYRH-HKUYNNGSSA-N

SMILES: FC(F)(F)C1=NN=NN1C2=CC=C(OC)C(=C2)CNC3CCCNC3C=4C=CC=CC4

Synonyms:

• (2S,3S)-N-[[2-Methoxy-5-[5-(trifluoromethyl)-1H-tetrazol-1-yl]phenyl]methyl]-2-phenyl-3-piperidinamine
• 3-Piperidinamine, N-[[2-methoxy-5-[5-(trifluoromethyl)-1H-tetrazol-1-yl]phenyl]methyl]-2-phenyl-, (2S,3S)-
• 3-Piperidinamine, N-[[2-methoxy-5-[5-(trifluoromethyl)-1H-tetrazol-1-yl]phenyl]methyl]-2-phenyl-, (2S-cis)-
• 3-piperidinamine, N-[[2-methoxy-5-[5-(trifluoromethyl)-1H-tetrazol-1-yl]phenyl]methyl]-2-phenyl-
• Gr 205171
• Vofopitant

GR 205171

CAS: 168266-90-8

Antagonist of neurokinin receptor NK1

• Formula: C₂₁H₂₃F₃N₆O
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 432.44 g/mol

Vofopitant

CAS: 168266-90-8

Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for …

• Formula: C₂₁H₂₃F₃N₆O
• Purity: 97.61%
• Color and Shape: Solid
• Molecular weight: 432.44