CAS 168273-06-1

Rimonabant

Description:

Rimonabant, with the CAS number 168273-06-1, is a selective cannabinoid receptor antagonist primarily known for its role in weight management and obesity treatment. It acts by blocking the CB1 receptors in the central nervous system, which are involved in appetite regulation and energy balance. This compound is characterized by its chemical formula C22H21Cl3N2O, and it features a complex structure that includes a tricyclic core. Rimonabant was initially marketed as an anti-obesity drug but was withdrawn from the market due to concerns about psychiatric side effects, including depression and anxiety. Its pharmacological profile also suggests potential applications in metabolic disorders, but the adverse effects have limited its use. Rimonabant is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Despite its withdrawal, research continues into its mechanisms and potential therapeutic uses, particularly in understanding the endocannabinoid system's role in various physiological processes.

Formula: C₂₂H₂₁Cl₃N₄O

InChI: InChI=1S/C22H21Cl3N4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)

InChI key: InChIKey=JZCPYUJPEARBJL-UHFFFAOYSA-N

SMILES: CC1=C(N(N=C1C(NN2CCCCC2)=O)C3=C(Cl)C=C(Cl)C=C3)C4=CC=C(Cl)C=C4

Synonyms:

• 1-(2,4-Dichlorophenyl)-5-(4-chlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide
• 1H-Pyrazole-3-carboxamide, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-
• 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid N-(piperidin-1-yl)amide
• 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide
• 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidinopyrazole-3-carboxamide
• 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide
• 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide hydrochloride (1:1)
• A 281
• Acomplia
• Enp 9
• N-Piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide
• Rimonabant(Acomplia,Sr141716)
• Sr 141617
• Sr 141716
• Zimulti

Rimonabant

CAS: 168273-06-1

Rimonabant (SR141716) is an inverse agonist for the cannabinoid receptor CB1.

Formula: C₂₂H₂₁Cl₃N₄O

Purity: 98% - 99.91%

Color and Shape: White Or Almost White Crystalline Powder

Molecular weight: 463.79

Ref: TM-T1519L

5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidinopyrazole-3-carboxamide

CAS: 168273-06-1

Formula: C₂₂H₂₁Cl₃N₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 463.7873

Ref: IN-DA00388V

Rimonabant base

CAS: 168273-06-1

Formula: C₂₂H₂₁Cl₃N₄O

Purity: ≥ 98%

Color and Shape: White to off-white powder or crystals

Molecular weight: 463.79

Ref: 7W-GX9120

Rimonabant

CAS: 168273-06-1

Formula: C₂₂H₂₁Cl₃N₄O

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 463.79

Ref: 3B-R0205

Rimonabant

Controlled Product

CAS: 168273-06-1

Cannabinoid receptor 1 (CB1) antagonist. Lowers consumption of food, via central and peripheral mechanisms. Reduces triglyceride and low-density lipoprotein levels (LDLs). Reduces nicotine dependence, potentially by modulating dopaminergic signalling. Serious adverse effects associated with Rimonabant include psychiatric disorders such as anxiety and depression.

Formula: C₂₂H₂₁Cl₃N₄O

Color and Shape: Powder

Molecular weight: 463.79 g/mol

Ref: 3D-FC61502

Rimonabant - Bio-X ™

Controlled Product

CAS: 168273-06-1

Rimonabant is cannabinoid receptor type 1 (CB1) inverse agonist drug. Rimonabant is used to treat obesity by reducing appetite and calorie intake. It lowers the consumption of food, via central and peripheral mechanisms. It also reduces triglyceride and low-density lipoprotein levels (LDLs). This drug has shown to reduce nicotine dependence, potentially by modulating dopaminergic signalling. >

Formula: C₂₂H₂₁Cl₃N₄O

Purity: Min. 99.0%

Color and Shape: Powder

Molecular weight: 463.79 g/mol

Ref: 3D-BR164345