CAS 168398-02-5

(2S,3S)-N-[2-methoxy-5-(1H-tetrazol-1-yl)benzyl]-2-phenylpiperidin-3-amine dihydrochloride

Description:

The chemical substance known as (2S,3S)-N-[2-methoxy-5-(1H-tetrazol-1-yl)benzyl]-2-phenylpiperidin-3-amine dihydrochloride, with the CAS number 168398-02-5, is a synthetic compound that belongs to the class of piperidine derivatives. It features a piperidine ring substituted with a phenyl group and a benzyl moiety that contains a methoxy and a tetrazole functional group. The presence of the tetrazole ring contributes to its potential biological activity, as tetrazoles are often found in pharmacologically active compounds. The dihydrochloride salt form indicates that the compound is likely a hydrochloride salt, which enhances its solubility in water, making it suitable for various applications, including pharmaceutical formulations. The stereochemistry denoted by (2S,3S) suggests specific spatial arrangements of the atoms, which can significantly influence the compound's biological interactions and efficacy. Overall, this compound may be of interest in medicinal chemistry, particularly in the development of therapeutics targeting specific biological pathways.

Formula: C₂₀H₂₅ClN₆O

InChI: InChI=1/C20H24N6O.2ClH/c1-27-19-10-9-17(26-14-23-24-25-26)12-16(19)13-22-18-8-5-11-21-20(18)15-6-3-2-4-7-15;;/h2-4,6-7,9-10,12,14,18,20-22H,5,8,11,13H2,1H3;2*1H/t18-,20-;;/m0../s1

InChI key: InChIKey=UYDCUPIPQXAELR-OINVMNEBSA-N

SMILES: N(CC1=C(OC)C=CC(=C1)N2C=NN=N2)[C@@H]3[C@@H](NCCC3)C4=CC=CC=C4.Cl

Synonyms:

• 3-Piperidinamine, N-[[2-methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-, hydrochloride (1:2), (2S,3S)-
• GR 203040
• 3-Piperidinamine, N-[[2-methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-, dihydrochloride, (2S,3S)-
• 3-Piperidinamine, N-[[2-methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-, dihydrochloride, (2S-cis)-
• (2S,3S)-N-[[2-Methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-3-piperidinamine hydrochloride (1:2)
• GR 203040(LS-113867)
• GR-203040 hydrochloride
• GR 203040 HCl,GR203040 HCl
• GR 203040; GR203040
• (2S,3S)-N-[[2-Methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride
• GR203040 >=98% (HPLC)
• GR-203040 HCl

3-Piperidinamine, N-[[2-methoxy-5-(1H-tetrazol-1-yl)phenyl]methyl]-2-phenyl-, hydrochloride (1:2), (2S,3S)-

CAS: 168398-02-5

Formula: C₂₀H₂₄N₆O

Molecular weight: 364.4442

Ref: IN-DA001Y14

GR 203040

CAS: 168398-02-5

Tachykinin receptor NK2 antagonist

Formula: C₂₀H₂₄N₆O·2HCl

Purity: Min. 95%

Molecular weight: 437.37 g/mol

Ref: 3D-BG166435

GR-203040 HCl

CAS: 168398-02-5

GR203040 inhibits cyclophosphamide-induced damage in the rat and ferret bladder. GR-203040 is a selective NK1 receptor antagonist.

Formula: C₂₀H₂₆Cl₂N₆O

Color and Shape: Solid

Molecular weight: 437.37

Ref: TM-T24102