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CAS 16846-34-7

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Leucomycin A1

Description:
Leucomycin A1 is a macrolide antibiotic that is derived from the fermentation of the bacterium *Streptomyces aureofaciens*. It is characterized by its large lactone ring structure, which is typical of macrolides, and it exhibits antibacterial activity primarily against Gram-positive bacteria. Leucomycin A1 is known for its ability to inhibit protein synthesis by binding to the 50S subunit of the bacterial ribosome, thereby preventing the growth and reproduction of susceptible bacteria. This compound is often used in clinical settings to treat various infections, particularly those caused by staphylococci and streptococci. Its pharmacological profile includes good tissue penetration and a relatively long half-life, which can contribute to its effectiveness in treating infections. However, like many antibiotics, it may also lead to the development of resistance if used improperly. Safety and efficacy profiles are important considerations in its therapeutic use, and it may have side effects that need to be monitored in patients receiving treatment.
Formula:C40H67NO14
InChI:InChI=1/C40H67NO14/c1-22(2)18-30(45)53-38-26(6)51-32(21-40(38,7)48)54-35-25(5)52-39(34(47)33(35)41(8)9)55-36-27(16-17-42)19-23(3)28(43)15-13-11-12-14-24(4)50-31(46)20-29(44)37(36)49-10/h11-13,15,17,22-29,32-39,43-44,47-48H,14,16,18-21H2,1-10H3/b12-11+,15-13+/t23-,24-,25-,26+,27+,28+,29-,32+,33-,34-,35-,36+,37+,38+,39+,40-/m1/s1
InChI key:InChIKey=IEMDOFXTVAPVLX-YWQHLDGFSA-N
SMILES:O([C@H]1[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]1OC)[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(CC(C)C)=O)[C@H](C)O3)[C@@H](C)O2
Synonyms:
  • 16846-34-7
  • 3-Deacetyljosamycin
  • 3-O-Deacetyljosamycin
  • Kitasamycin A<sub>1</sub>
  • Leucomycin A<sub>1</sub>
  • Leucomycin V 4-isovalerate
  • Leucomycin V, 4<sup>B</sup>-(3-methylbutanoate)
  • Oxacyclohexadecane, leucomycin V deriv.
  • Turimycin H<sub>5</sub>
  • Kitasamycin A1
  • See more synonyms
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