CAS 168482-23-3

N-Acetyl-L-norleucyl-L-aspartyl-L-histidyl-3-(2-naphthyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysinamide cyclic C-4.2-N-6.7-amide

Description:

N-Acetyl-L-norleucyl-L-aspartyl-L-histidyl-3-(2-naphthyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysinamide cyclic C-4.2-N-6.7-amide, with CAS number 168482-23-3, is a synthetic peptide that exhibits a complex structure characterized by a cyclic arrangement of amino acids. This compound features a combination of both L- and D-amino acids, which can influence its biological activity and stability. The presence of the naphthyl group suggests potential interactions with aromatic systems, which may enhance its binding affinity to specific biological targets. The acetylation at the N-terminus typically improves solubility and bioavailability. Peptides like this one are often studied for their potential therapeutic applications, including roles in drug design, as they can mimic natural biological processes or inhibit specific pathways. The cyclic nature of this peptide may confer additional stability against enzymatic degradation, making it a candidate for further research in pharmacology and biochemistry. Overall, its unique structure and composition suggest a multifaceted role in biological systems.

Formula: C₅₄H₇₁N₁₅O₉

InChI: InChI=1/C54H71N15O9/c1-3-4-15-40(63-31(2)70)48(73)68-45-27-46(71)59-21-10-9-17-41(50(75)69-53(78)44(67-52(45)77)26-36-29-58-30-62-36)65-51(76)43(25-35-28-61-39-16-8-7-14-37(35)39)66-49(74)42(18-11-22-60-54(56)57)64-47(72)38(55)24-32-19-20-33-12-5-6-13-34(33)23-32/h5-8,12-14,16-17,19-20,23,29-30,35-36,38,40,42-45,61H,3-4,9-11,15,18,21-22,24-28,55H2,1-2H3,(H,59,71)(H,63,70)(H,64,72)(H,65,76)(H,66,74)(H,67,77)(H,68,73)(H4,56,57,60)(H,69,75,78)/b41-17+/t35?,36?,38-,40+,42+,43+,44+,45+/m1/s1

Synonyms:

• Mbx-36
• Shu-9119
• 3-naphthalen-2-yl-D-alanyl-N5-(diaminomethylidene)-L-ornithyl-N-[(3S,6S,13E)-6-[(N-acetyl-L-norleucyl)amino]-3-(4H-imidazol-4-ylmethyl)-2,5,8,15-tetraoxo-1,4,9-triazacyclopentadec-13-en-14-yl]-3-(2,3-dihydro-1H-indol-3-yl)-L-alaninamide

SHU 9119

CAS: 168482-23-3

SHU 9119 is a potent antagonist for human MC3R/MC4R and partial agonist for MC5R with IC50 values of 0.23, 0.06, 0.09 nM.

Formula: C₅₄H₇₁N₁₅O₉

Purity: 98%

Color and Shape: Solid

Molecular weight: 1074.258

Ref: TM-T16879

N-Acetyl-L-norleucyl-L-a-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysinamide-(2,7) -lactam

CAS: 168482-23-3

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Formula: C₅₄H₇₁N₁₅O₉

Purity: Min. 95%

Molecular weight: 1,074.24 g/mol

Ref: 3D-FA109130

Acetyl-(Nle⁴,Asp⁵,D-2-Nal⁷,Lys¹⁰)-cyclo-α-MSH (4-10) amide

CAS: 168482-23-3

Screening analogs of the cyclic lactam melanocortin agonist MTII led to the identification of the agoutimimetic SHU9119. The cyclopeptide SHU9119 shares pharmacological properties with the agouti peptide in that it is a potent antagonist of the melanocortin-4 receptor and a less potent antagonist of the melanocortin-3 receptor.

Formula: C₅₄H₇₁N₁₅O₉

Purity: 98.3%

Color and Shape: White Lyophilisate

Molecular weight: 1074.25

Ref: 01-4027601