CAS 168555-66-6

Fosbretabulin disodium

Description:

Fosbretabulin disodium is a small molecule that acts as an anti-cancer agent, primarily functioning as a vascular disrupting agent. It is designed to target and disrupt the blood supply to tumors, thereby inhibiting their growth and promoting tumor cell death. The compound is a prodrug of the active agent fosbretabulin, which is derived from the natural product combretastatin A-4. Fosbretabulin disodium is typically administered intravenously and has been investigated in clinical trials for various types of cancer, including advanced solid tumors. Its mechanism of action involves the destabilization of the cytoskeleton in endothelial cells, leading to the collapse of tumor vasculature. The disodium salt form enhances its solubility and bioavailability. As with many anti-cancer therapies, potential side effects may include vascular-related complications, fatigue, and gastrointestinal disturbances. Ongoing research continues to explore its efficacy and safety profile in combination with other therapeutic agents.

Formula: C₁₈H₂₁O₈P·2Na

InChI: InChI=1S/C18H21O8P.2Na/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3;;/h5-11H,1-4H3,(H2,19,20,21);;/b6-5-;;

InChI key: InChIKey=ACFUENHANVNJPF-XNOMRPDFSA-N

SMILES: O(P(=O)(O)O)C1=C(OC)C=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=C1.[Na]

Synonyms:

• 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol dihydrogen phosphate disodium salt
• Ca 4Dp
• Ca 4P
• Ca4P
• CombretastatinA4disodiumphosphate(CA4P)
• Fosbretabulin disodium
• Fosbretabulin disodium salt
• Ombretastatin A-4 Phosphate, Disodium Salt
• Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, 1-(dihydrogen phosphate), sodium salt (1:2)
• Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, dihydrogen phosphate, disodium salt
• Phenol, 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]-, dihydrogen phosphate, disodium salt, (Z)-
• Sml1131
• disodium 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl phosphate

Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, 1-(dihydrogen phosphate), sodium salt (1:2)

CAS: 168555-66-6

Formula: C₁₈H₁₉Na₂O₈P

Purity: 98%

Color and Shape: Solid

Molecular weight: 440.2920

Ref: IN-DA001Y5B

Fosbretabulin Disodium

CAS: 168555-66-6

Fosbretabulin Disodium

Purity: ≥95%

Molecular weight: 440.29g/mol

Ref: 54-BUP02087

Combretastatin A4 Phosphate Disodium Salt

CAS: 168555-66-6

Formula: C₁₈H₁₉Na₂O₈P

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 440.30

Ref: 3B-C3009

Fosbretabulin Disodium

CAS: 168555-66-6

Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).

Formula: C₁₈H₁₉O₈P·2Na

Purity: 97.43% - 99.96%

Color and Shape: White Solid

Molecular weight: 440.29

Ref: TM-T6272

Combretastatin A4 Phosphate Disodium Salt

Controlled Product

CAS: 168555-66-6

Applications Phosphorylated Combretastatin, a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.
References Hamel, E., et al.: Biochem. Pharmacol., 32, 3863 (1983), Chaplin, D.J., et al.: Br. J. Cancer, 74, S86, (1996)

Formula: C₁₈H₁₉O₈P·2Na

Color and Shape: Neat

Molecular weight: 440.29

Ref: TR-C643025