CAS 168650-46-2

(Asp371)-Tyrosinase (369-377) (human)

Description:

(Asp371)-Tyrosinase (369-377) is a peptide derived from the human tyrosinase enzyme, which plays a crucial role in the biosynthesis of melanin, the pigment responsible for coloration in skin, hair, and eyes. This specific peptide sequence is part of the larger tyrosinase protein and is involved in the enzyme's catalytic activity, facilitating the oxidation of phenolic compounds to produce melanin. The CAS number 168650-46-2 identifies this particular peptide, indicating its unique chemical identity. Tyrosinase is a copper-containing enzyme, and its activity is influenced by various factors, including pH, temperature, and the presence of inhibitors or activators. The study of this peptide can provide insights into skin pigmentation disorders and potential therapeutic approaches for conditions such as albinism or hyperpigmentation. Additionally, understanding the structure and function of tyrosinase can aid in the development of cosmetic products aimed at skin lightening or protection against UV radiation.

Formula: C₄₂H₆₆N₁₀O₁₆S₂

Synonyms:

• [Asp370]-Tyrosinase (368-376)
• Asp371, Tyrosinase 369-777, Human
• Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val
• Ymdgtmsqv

[Asp371]-Tyrosinase (369-377), human

CAS: 168650-46-2

Tyrosinase (369-377,YMDGTMSQV) originates from tyrosinase and needs TAP and proteosome for cell presentation.

Formula: C₄₂H₆₆N₁₀O₁₆S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 1031.16

Ref: TM-TP1623

[Asp371]-Tyrosinase (369-377), human

CAS: 168650-46-2

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₄₂H₆₆N₁₀O₁₆S₂

Molecular weight: 1,031.2 g/mol

Ref: 3D-PP50380

[Asp371] Tyrosinase(369-377), human

CAS: 168650-46-2

H-YMDGTMSQVA-OH peptide, corresponding to 369-377 amino acids of enzyme tyrosinase. As a member of the tyrosinase family the corresponding enzyme catalyzes monopheol hydroxylation, dihydroxyindole and catechol dehydrogenation. It is a key enzyme in the conversion of tyrosine to melanin.

Formula: C₄₂H₆₆N₁₀O₁₆S₂

Purity: Min. 95%

Molecular weight: 1,031.16 g/mol

Ref: 3D-FA73646

(Asp371)-Tyrosinase (369-377) (human) acetate salt

CAS: 168650-46-2

Tyrosinase protein:
Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV) is a human tyrosinase-derived (369-377) peptide by posttranslational conversion of the sequence YMNGTMSQV. Tyrosinase is an oxidase membrane-bound protein. Tyrosinase play a key role in the melanin synthesis pathway. Tyrosinase is presented on the surface of HLA-A*02:01 melanomas and also expressed in melanocytes. Tyrosinase has been still suggested to be a tumor antigen and might be implicated in improvement of immunotherapeutic strategies such as for efficient anticancer vaccine development.
Applications of Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV):
Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV) is used to stimulate specific cytotoxic T lymphocytes (CTL) in PBMCs and then to analyze CTL response especially the cytokine production by ELISPOT assay. Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV) is also involved in experimental therapies of metastatic melanoma by allogeneic hematopoietic stem cell transplantation. In fact, cytotoxic T cells were generated from peripherical blood mononuclear cells (PBMCs) of HLA-A*02:01 healthy donors after being stimulated by injection of Asp371 antigen (2). This strategy raises issues which concern the graft versus tumor (GvT) effect and graft versus host disease (GvHD).

Formula: C₄₂H₆₆N₁₀O₁₆S₂

Purity: Min. 95%

Molecular weight: 1,031.16 g/mol

Ref: 3D-FA109106

(Asp371)-Tyrosinase (369-377) (human) trifluoroacetate salt

CAS: 168650-46-2

Trifluoroacetate salt

Formula: C₄₂H₆₆N₁₀O₁₆S₂

Purity: Min. 95%

Molecular weight: 1,031.16 g/mol

Ref: 3D-FA110240