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CAS 168701-80-2

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8-NITROGUANINE

Description:
8-Nitroguanine is a modified nucleobase that is derived from guanine, one of the four primary building blocks of DNA and RNA. It is characterized by the presence of a nitro group (-NO2) at the 8-position of the guanine structure, which can influence its chemical properties and biological interactions. This modification can lead to increased mutagenicity and has been implicated in various biological processes, including DNA damage and repair mechanisms. 8-Nitroguanine can form stable base pairs with cytosine, potentially leading to G:C to A:T transitions during DNA replication. Its presence in DNA is often associated with oxidative stress and has been studied in the context of various diseases, including cancer. The compound is typically analyzed using techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry to understand its role in biological systems and its potential as a biomarker for oxidative damage. Overall, 8-nitroguanine serves as an important subject of study in the fields of molecular biology and medicinal chemistry.
Formula:C5H4N6O3
InChI:InChI=1/C5H4N6O3/c6-4-8-2-1(3(12)10-4)7-5(9-2)11(13)14/h(H4,6,7,8,9,10,12)
SMILES:c12c([nH]c(=N)nc1O)[nH]c(n2)N(=O)=O
Synonyms:
  • 8-No2-Gua
  • 2-amino-8-nitro-3,7-dihydro-6H-purin-6-one
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Found 4 products.
  • 2-Amino-8-nitro-7H-purin-6-ol
    Indagoo
    + Info

    2-Amino-8-nitro-7H-purin-6-ol

    CAS:
    Formula:C5H4N6O3
    Color and Shape:Solid
    Molecular weight:196.1237

    Ref: IN-DA001Y8L

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    To inquire
  • 8-Nitroguanine
    Targetmol
    + Info

    8-Nitroguanine

    CAS:
    <p>8-Nitroguanine is a product of DNA nitration damage caused by reactive nitrogen species and may be a potential biomarker for the progression of malignant</p>
    Formula:C5H4N6O3
    Color and Shape:Solid
    Molecular weight:196.12

    Ref: TM-T36697

  • 8-Nitroguanine
    TRC
    + Info

    8-Nitroguanine

    Controlled Product
    CAS:
    <p>Applications 8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer.<br>References Surh, Y., et al.: Mutat. Res., 480, 243 (2001), Balkwill, F., et al.: Lancet, 357, 539 (2001), Kawanishi, S., et al.: Biol. Chem., 387, 365 (2006), Hoki, Y., et al.: Cancer Sci., 98, 163 (2007),<br></p>
    Formula:C5H4N6O3
    Color and Shape:Neat
    Molecular weight:196.12

    Ref: TR-N496010

    1mg
    125.00€
    5mg
    209.00€
    10mg
    304.00€
  • 8-Nitroguanine
    Biosynth
    + Info

    8-Nitroguanine

    CAS:
    <p>8-Nitroguanine is a reactive cell factor that can be found in the skin and other tissues. It is an endogenous product of nitric oxide, which can be formed by the reaction of nitric oxide with superoxide in the presence of peroxynitrite. 8-Nitroguanine has been shown to inhibit matrix metalloproteinase-9 activity and to have a protective effect on cells from UV radiation. 8-Nitroguanine also has been shown to be a potential biomarker for bowel disease and damage. The levels of 8-nitroguanine increase in chronic viral hepatitis and cancer tissues. This compound can also be used as an analytical method for detection of inflammation, oxidative stress, or DNA damage.</p>
    Formula:C5H4N6O3
    Purity:Min. 95%
    Color and Shape:Powder
    Molecular weight:196.13 g/mol

    Ref: 3D-FN09065

    5mg
    478.00€
    10mg
    607.00€