CAS 16891-85-3

Roridin E

Description:

Roridin E is a mycotoxin produced by certain species of fungi, particularly those in the genus *Fusarium*. It is classified as a macrocyclic trichothecene, which are known for their potent biological activity and toxicity. Roridin E exhibits characteristics typical of trichothecenes, including the ability to inhibit protein synthesis in eukaryotic cells, leading to cytotoxic effects. This compound is often studied for its implications in food safety and human health, as it can contaminate agricultural products, particularly grains. Its structure features a complex ring system that contributes to its stability and biological activity. Roridin E is also known to induce various toxicological effects, including immunosuppression and potential carcinogenicity. Due to its toxicity, it is important to monitor and regulate levels of Roridin E in food and feed products to prevent adverse health effects in humans and animals. Research continues to explore its mechanisms of action and potential mitigation strategies in contaminated environments.

Formula: C₂₉H₃₈O₈

InChI: InChI=1/C29H38O8/c1-18-9-11-28-16-34-26(32)14-19(2)10-12-33-21(20(3)30)7-5-6-8-25(31)37-22-15-24(36-23(28)13-18)29(17-35-29)27(22,28)4/h5-8,13-14,20-24,30H,9-12,15-17H2,1-4H3/b7-5-,8-6-,19-14-/t20-,21-,22-,23-,24?,27-,28-,29+/m1/s1

InChI key: InChIKey=KEEQQEKLEZRLDS-CBOTUIHUSA-N

SMILES: C[C@@]12[C@@]3([C@]4(C[C@]1(OC(=O)/C=C/C=C/[C@]([C@@H](C)O)(OCC/C(/C)=C\C(=O)OC[C@]25[C@](O4)(C=C(C)CC5)[H])[H])[H])[H])CO3

Synonyms:

• (2′E,7′R)-2′,3′-Didehydro-7′-deoxo-2′-deoxy-7′-[(1R)-1-hydroxyethyl]verrucarin A
• (4E,9R,10E,12Z,16R,16aS,18R,19aR,23aR)-9-[(1R)-1-hydroxyethyl]-5,16a,21-trimethyl-6,7,16,16a,22,23-hexahydro-3H,18H,19aH-spiro[16,18-methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene-17,2'-oxirane]-3,14(9H)-dione
• (4Z,9R,10Z,12Z,16R,16aS,17S,19aR,23aR)-9-[(1R)-1-hydroxyethyl]-5,16a,21-trimethyl-6,7,16,16a,22,23-hexahydro-3H,18H,19aH-spiro[16,18-methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene-17,2'-oxirane]-3,14(9H)-dione
• Roridine E
• Roridinee
• Spiro[16,18-methano-1H,3H,23H-[1,6,12]trioxacyclooctadecino[3,4-d][1]benzopyran-17(18H),2′-oxirane], verrucarin A deriv.
• Verrucarin A, 2′,3′-didehydro-7′-deoxo-2′-deoxy-7′-(1-hydroxyethyl)-, [2′E,7′R(R)]-
• Verrucarin A, 2′,3′-didehydro-7′-deoxo-2′-deoxy-7′-[(1R)-1-hydroxyethyl]-, (2′E,7′R)-
• Verrucarina,2’,3’-Didehydro-7’-Deoxo-2’-Deoxy-7’-(1-Hydroxyethyl)-,(2’E,7’R(
• Roridin E

Roridin E

CAS: 16891-85-3

Formula: C₂₉H₃₈O₈

Purity: >97%

Color and Shape: white. Solid

Molecular weight: 514.0

Ref: 8R-AD0001

Roridin E

CAS: 16891-85-3

Roridin E

Molecular weight: 514.611g/mol

Ref: 54-BI9887

Roridin E

CAS: 16891-85-3

Formula: C₂₉H₃₈O₈

Molecular weight: 514.62

Ref: 4Z-R-113002

Roridin E

CAS: 16891-85-3

Ref: 7W-GW2731

Roridin E

CAS: 16891-85-3

Roridin E is a macrocyclic trichothecene mycotoxin, which is derived from fungi, particularly those within the genus Myrothecium. It is characterized by its complex ring structure, which contributes to its unique biological activity. The mode of action of Roridin E involves the inhibition of protein synthesis by binding to the ribosomal peptidyl transferase center, ultimately disrupting cellular processes and inducing cytotoxic effects.

Formula: C₂₉H₃₈O₈

Purity: Min. 95%

Molecular weight: 514.25667

Ref: 3D-FR178284

Roridin E

CAS: 16891-85-3

Roridin E blocks FGFR3, IGF-1R, PDGFRβ, TrkB (IC50s: 0.4–1.4 μM), kills breast cancer cells (IC50: 0.02-0.05 nM), and halts other cancer cells (<0.01 μM).

Formula: C₂₉H₃₈O₈

Color and Shape: Solid

Molecular weight: 514.61

Ref: TM-T70276