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CAS 16893-05-3

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cis-Diamminetetrachloroplatinum

Description:
Cis-Diamminetetrachloroplatinum, commonly known as cisplatin, is a platinum-based chemotherapy drug widely used in cancer treatment. Its chemical formula is [Pt(NH3)2Cl2], indicating that it contains a platinum center coordinated to two ammonia (NH3) ligands and two chloride (Cl) ligands. The "cis" configuration refers to the spatial arrangement of the ligands around the platinum atom, which is crucial for its biological activity. Cisplatin is known for its ability to form DNA cross-links, leading to the inhibition of DNA replication and ultimately triggering apoptosis in cancer cells. This mechanism makes it effective against various types of cancers, including testicular, ovarian, and bladder cancers. The compound is typically administered intravenously and can have side effects such as nephrotoxicity, nausea, and myelosuppression. Due to its significant role in oncology, cisplatin has been the subject of extensive research to improve its efficacy and reduce side effects, leading to the development of various platinum-based analogs.
Formula:Cl4H6N2Pt
InChI:InChI=1S/4ClH.2H3N.Pt/h4*1H;2*1H3;/q;;;;;;+4/p-4
InChI key:InChIKey=RBHOYUZKIANPPG-UHFFFAOYSA-J
SMILES:[Pt+4]([Cl-])([Cl-])([Cl-])([Cl-])([NH3])[NH3]
Synonyms:
  • (OC-6-22)-Diamminetetrachloroplatinum
  • Jm 190
  • NSC 119876
  • Platinum(4+) Chloride Ammoniate (1:4:2)
  • Platinum, diamminetetrachloro-, (OC-6-22)-
  • Platinum, diamminetetrachloro-, cis-
  • Tetrachloroplatinum(2+) Diazanide
  • cis Tetrachlorodiammineplatinum
  • cis-Bisamminetetrachloroplatinum
  • cis-Diamminetetrachloroplatinum
  • See more synonyms
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