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CAS 16893-06-4

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trans-Diamminetetrachloroplatinum

Description:
Trans-Diamminetetrachloroplatinum, commonly known as trans-DDP, is a coordination compound of platinum with the chemical formula [Pt(NH3)2Cl4]. It is characterized by its square planar geometry, where a platinum(II) center is coordinated to two ammonia (NH3) ligands and four chloride (Cl) ligands in a trans configuration. This compound is notable for its potential use in cancer therapy, particularly as an alternative to its cis isomer, cisplatin, which is widely used in chemotherapy. The trans isomer exhibits different biological activity and may have distinct pharmacological properties. In terms of solubility, trans-DDP is generally less soluble in water compared to cisplatin, which can influence its bioavailability and therapeutic efficacy. The compound's stability and reactivity are also significant, as they affect its interaction with cellular components. Overall, trans-Diamminetetrachloroplatinum represents an important area of research in medicinal chemistry, particularly in the development of platinum-based anticancer agents.
Formula:Cl4H6N2Pt
InChI:InChI=1/4FH.2H3N.Pt/h4*1H;2*1H3;/q;;;;;;+4/p-4
InChI key:InChIKey=RBHOYUZKIANPPG-UHFFFAOYSA-J
SMILES:[Pt+4]([Cl-])([Cl-])([Cl-])([Cl-])([NH3])[NH3]
Synonyms:
  • (OC-6-11)-Diamminetetrachloroplatinum
  • NSC 123895
  • Platinum(4+) Tetrafluoride Diammoniate
  • Platinum, diamminetetrachloro-, (OC-6-11)-
  • Platinum, diamminetetrachloro-, trans-
  • trans Tetrachlorodiammineplatinum
  • trans-Bisamminetetrachloroplatinum
  • trans-Diamminetetrachloroplatinum
  • trans-Diamminetetrachloroplatinum(IV)
  • trans-Platinumdiammine tetrachloride
  • See more synonyms
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