CAS 169105-89-9: Isofagomine

Description: Isofagomine is a chemical compound characterized as a potent and selective inhibitor of the enzyme glucocerebrosidase, which is crucial in the metabolism of glycosphingolipids. It is primarily studied for its potential therapeutic applications in treating Gaucher disease, a genetic disorder resulting from glucocerebrosidase deficiency. Isofagomine is known for its ability to stabilize the enzyme in its active form, thereby enhancing its activity and promoting the breakdown of glucocerebrosides. The compound features a unique bicyclic structure that contributes to its binding affinity and specificity for the enzyme. Isofagomine is typically administered in a pharmaceutical context, and its efficacy is evaluated through various biochemical assays and clinical studies. Additionally, it is important to consider its pharmacokinetics, potential side effects, and interactions with other medications when assessing its therapeutic use. Overall, isofagomine represents a significant advancement in the treatment of lysosomal storage disorders, highlighting the importance of enzyme replacement and enhancement therapies in modern medicine.

Formula: C₆H₁₃NO₃

InChI: InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1

InChI key: InChIKey=QPYJXFZUIJOGNX-HSUXUTPPSA-N

SMILES: OCC1CNCC(O)C1O

Synonyms:

• (3R,4R,5R)-5-(Hydroxymethyl)-3,4-Piperidinediol, Hydrochloride
• (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol
• (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol,HCl
• (3R,4R,5S)-5-(hydroxymethyl)piperidine-3,4-diol
• 3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5R)-
• 3,4-Piperidinediol, 5-(hydroxymethyl)-, [3R-(3α,4β,5α)]-
• <span class="text-smallcaps">D</span>-Isofagomine
• Afegostat
• Isofagomine
• IsofagomineHydrochlroide
• Plicera
• D-Isofagomine

3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4R,5R)-

CAS: 169105-89-9

• Formula: C₆H₁₃NO₃
• Molecular weight: 147.1723

Isofagomine

CAS: 169105-89-9

• Formula: C₆H₁₃NO₃
• Color and Shape: Neat
• Molecular weight: 147.172

Isofagomine

CAS: 169105-89-9

Isofagomine is a chiral molecule that has been used as a model system for studying …

• Formula: C₆H₁₃NO₃
• Purity: Min. 95%
• Molecular weight: 147.17 g/mol

Afegostat

CAS: 169105-89-9

Afegostat is a pharmacological chaperone that specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic …

• Formula: C₆H₁₃NO₃
• Purity: 98%
• Color and Shape: Yellow Low-Melting Solid
• Molecular weight: 147.17