CAS 169280-56-2

4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide

Description:

4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide, with CAS number 169280-56-2, is a chemical compound characterized by its complex structure, which includes an amino group, a sulfonamide moiety, and a chiral center. This compound features a phenylbutyl chain that contributes to its hydrophobic properties, while the sulfonamide group enhances its solubility in polar solvents. The presence of multiple functional groups, including amino and hydroxyl groups, suggests potential for hydrogen bonding, which can influence its biological activity and interactions with other molecules. The stereochemistry indicated by the (2R,3S) configuration is crucial for its pharmacological properties, as it may affect the compound's binding affinity to biological targets. This compound is likely to be of interest in medicinal chemistry, particularly in the development of pharmaceuticals, due to its potential therapeutic applications. Its stability, reactivity, and solubility characteristics would be essential for understanding its behavior in biological systems and its suitability for drug formulation.

Formula: C₂₀H₂₉N₃O₃S

InChI: InChI=1S/C20H29N3O3S/c1-15(2)13-23(27(25,26)18-10-8-17(21)9-11-18)14-20(24)19(22)12-16-6-4-3-5-7-16/h3-11,15,19-20,24H,12-14,21-22H2,1-2H3/t19-,20+/m0/s1

InChI key: InChIKey=NUMJNKDUHFCFJO-VQTJNVASSA-N

SMILES: N(S(=O)(=O)C1=CC=C(N)C=C1)(C[C@H]([C@H](CC2=CC=CC=C2)N)O)CC(C)C

Synonyms:

• 4-Amino-(2R,3S)-N-(3-Amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-benzenesulfonamide
• 4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide
• 4-Amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)benzenesulfonamide
• 4-Amino-N-[(2r,3s)-3-Amino-2-Hydroxy-4-Phenyl butyl]-N-Isobutylbenzenesulfonamide(D7)
• Benzenesulfonamide, 4-amino-N-(3-amino-2-hydroxy-4-phenylbutyl)-N-(2-methylpropyl)-, [R-(R*,S*)]-
• Benzenesulfonamide, 4-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)-

4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide

CAS: 169280-56-2

Formula: C₂₀H₂₉N₃O₃S

Purity: 95%

Color and Shape: Solid

Molecular weight: 391.5276

Ref: IN-DA0033WO

4-Amino-N-(2R,3S)(3-Amino-2-Hydroxy-4-Phenylbutyl)-N-Isobutylbenzenesulfonamide

CAS: 169280-56-2

4-Amino-N-(2R,3S)(3-Amino-2-Hydroxy-4-Phenylbutyl)-N-Isobutylbenzenesulfonamide

Purity: 98%

Molecular weight: 391.53g/mol

Ref: 54-OR1011428

Darunavir Impurity 35

CAS: 169280-56-2

Formula: C₂₀H₂₉N₃O₃S

Color and Shape: Off-White Solid

Molecular weight: 391.53

Ref: 4Z-D-3719

4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-(2-methylpropyl)benzenesulfonamide

CAS: 169280-56-2

Color and Shape: Neat

Ref: 86-MM3624.06

4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-ispobutylbenzenesulfonamide

CAS: 169280-56-2

4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide is an amide that is used to treat HIV infections. It has been shown to have potent anti-viral activity against HIV infected cells in the laboratory and can inhibit the replication of HIV by interfering with the virus's ability to use the reverse transcriptase enzyme. 4ABAB has been shown to bind to the enzyme ribonuclease H (crth2), which is responsible for breaking down viral RNA. This binding prevents crth2 from cleaving viral RNA, thus inhibiting DNA synthesis and preventing cell death. 4ABAB also interferes with a hydrogen bond between ethyl group and the hydroxyl group on crth2, leading to a decrease in activity.

Formula: C₂₀H₂₉N₃O₃S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 391.53 g/mol

Ref: 3D-FA58013

4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide

CAS: 169280-56-2

Formula: C₂₀H₂₉N₃O₃S

Purity: 95%

Molecular weight: 391.53

Ref: 10-F225382

4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide

Controlled Product

CAS: 169280-56-2

Applications A metabolite of Darunavir.
References Debouck, C., et al.: Drug Dev. Res., 21, 1 (1990), Krohn, A., et al.: J. Med. Chem., 34, 3340 (1991), Vazquez, M., et al.: J. Med. Chem., 38, 581 (1995),

Formula: C₂₀H₂₉N₃O₃S

Color and Shape: Neat

Molecular weight: 391.5276

Ref: TR-A581400

Darunavir Impurity A

CAS: 169280-56-2

Formula: C₂₀H₂₉N₃O₃S

Molecular weight: 391.53

Ref: ST-EA-CP-D70005