CAS 169293-50-9

Nebivolol hydrochloride

Description:

Nebivolol hydrochloride is a selective beta-1 adrenergic receptor blocker primarily used in the treatment of hypertension and heart failure. It is characterized by its ability to lower blood pressure by reducing heart rate and myocardial contractility, while also promoting vasodilation through the release of nitric oxide. This dual mechanism makes it unique among beta-blockers. The substance is typically presented as a white to off-white crystalline powder, soluble in water and methanol, which facilitates its formulation in various pharmaceutical preparations. Nebivolol exhibits a favorable pharmacokinetic profile, with a long half-life that allows for once-daily dosing. Its selectivity for beta-1 receptors minimizes the risk of bronchoconstriction, making it a safer option for patients with respiratory conditions. Additionally, nebivolol has been noted for its antioxidant properties, which may contribute to its cardiovascular benefits. As with any medication, potential side effects include fatigue, dizziness, and bradycardia, necessitating careful monitoring during treatment.

Formula: C₂₂H₂₆ClF₂NO₄

InChI: InChI=1/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H

SMILES: C1CC(C(CNCC(C2CCc3cc(ccc3O2)F)O)O)Oc2ccc(cc12)F.Cl

Synonyms:

• Rac Nebivolol, Hydrochloride
• a,a(Iminodimethylene)bis[6-fluoro-2-chromanmethanol] Hydrochloride
• Lobivon
• Nebilet
• Nebilox
• R-67555
• Nebivololhydrochloride(Subjecttopatentfree)
• a,a'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride
• Nebivolol hcl
• 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] hydrochloride

Nebivolol HCl

CAS: 169293-50-9

Formula: C₂₂H₂₆ClF₂NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 441.8959

Ref: IN-DA00AOO3

rac Nebivolol Hydrochloride

Controlled Product

CAS: 169293-50-9

Formula: C₂₂H₂₅F₂NO₄·ClH

Color and Shape: White To Off-White

Molecular weight: 441.90

Ref: TR-N387900

rac Nebivolol-d8 Hydrochloride

Controlled Product

CAS: 169293-50-9

Formula: C₂₂D₈H₁₇F₂NO₄·HCl

Color and Shape: Neat

Molecular weight: 449.945

Ref: TR-N387904