CAS 16937-99-8

tert-Butoxycarbonyl-D-leucine

Description:

Tert-Butoxycarbonyl-D-leucine, commonly abbreviated as Boc-D-leucine, is a derivative of the amino acid leucine, characterized by the presence of a tert-butoxycarbonyl (Boc) protecting group. This compound is typically utilized in peptide synthesis as a protective group for the amino functionality, which helps to prevent unwanted reactions during the synthesis process. The Boc group is known for its stability under basic conditions and can be easily removed under acidic conditions, making it a popular choice in organic synthesis. Tert-Butoxycarbonyl-D-leucine is a white to off-white solid, and its molecular structure includes a branched aliphatic side chain, characteristic of leucine, which contributes to its hydrophobic properties. The compound is soluble in organic solvents such as dichloromethane and dimethylformamide but has limited solubility in water. Its applications extend beyond peptide synthesis to include studies in biochemistry and medicinal chemistry, where it serves as a building block for various bioactive compounds.

Formula: C₁₁H₂₁NO₄

InChI: InChI=1S/C11H21NO4/c1-7(2)6-8(9(13)14)12-10(15)16-11(3,4)5/h7-8H,6H2,1-5H3,(H,12,15)(H,13,14)/t8-/m1/s1

InChI key: InChIKey=MDXGYYOJGPFFJL-MRVPVSSYSA-N

SMILES: [C@@H](NC(OC(C)(C)C)=O)(CC(C)C)C(O)=O

Synonyms:

• (2R)-2-[[(tert-Butoxy)carbonyl]amino]-4-methylpentanoic acid
• (2R)-4-Methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid
• (R)-2-(tert-Butoxycarbonylamino)-4-methylpentanoic acid
• (R)-2-[[tert-Butoxycarbonyl)amino]-4-methylpentanoicacid
• (R)-N-(t-Butoxycarbonyl)leucine
• <span class="text-smallcaps">D</span>-Boc leucine
• <span class="text-smallcaps">D</span>-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-
• Boc-D-Leu-OH hydrate
• Boc-D-Leu-OH.H2O
• Boc-D-Leu-Oh
• Boc-D-Leucine
• L-Leucine-5,5,5-D3, N-T-Boc Deriv.H20
• Leucine, N-carboxy-, N-tert-butyl ester, <span class="text-smallcaps">D</span>-
• N-(Tert-Butoxycarbonyl)-D-Leucine
• N-(tert-Butoxycarbonyl)-<span class="text-smallcaps">D</span>-leucine
• N-(tert-butoxycarbonyl)-D-leucine hydrate
• N-Alpha-T-Boc-D-Leucine
• N-Boc-<span class="text-smallcaps">D</span>-leucine
• N-Boc-D-Leu-OH monohydrate
• N-T-Boc-D-Leucine
• N-Tert-Butoxycarbonyl-D-Leucine 1-Hydrate
• N-[(1,1-Dimethylethoxy)carbonyl]-<span class="text-smallcaps">D</span>-leucine
• tert-Butoxycarbonyl-<span class="text-smallcaps">D</span>-leucine
• Leucine, N-carboxy-, N-tert-butyl ester, D-
• N-[(1,1-Dimethylethoxy)carbonyl]-D-leucine
• D-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-

N-(tert-Butoxycarbonyl)-D-leucine Monohydrate

CAS: 16937-99-8, 200937-17-3

Formula: C₁₁H₂₁NO₄·H₂O

Purity: >98.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 249.31

Ref: 3B-B3007

N-Boc-D-leucine hydrate, 98+%

CAS: 16937-99-8

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₁H₂₃NO₅

Purity: 98+%

Color and Shape: Crystals or powder or crystalline powder, White

Molecular weight: 249.31

Ref: 02-L09124

Boc-D-Leu-OH · H₂O

CAS: 16937-99-8

Bachem ID: 4002976.

Formula: C₁₁H₂₁NO₄·H₂O

Purity: > 99%

Color and Shape: White

Molecular weight: 249.31

Ref: 01-4002976

D-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-

CAS: 16937-99-8

Formula: C₁₁H₂₃NO₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 249.3040

Ref: IN-DA00IKJ0

Boc-D-Leu-OH

CAS: 16937-99-8

Formula: C₁₁H₂₁NO₄xH₂O

Molecular weight: 231.29

Ref: 7W-GM6632

Boc-D-leucine

CAS: 16937-99-8

Boc-D-leucine

Purity: 98%

Molecular weight: 231.29g/mol

Ref: 54-OR452082

N-Boc-D-leucine

Controlled Product

CAS: 16937-99-8

Applications N-Boc-D-leucine is an N-Boc-protected form of D-Leucine (L330150). D-Leucine is an unnatural isomer of L-Leucine (L330110) that acts as an auto-inhibitor of lactic streptococci in culture. D-Leucine causes analgesia in humans and also exhibits inhibitory activity in bacterial cell cultures.
References Chuan, Y., et al.: Chin. J. Anim. Vet. Sci., 4, 003 (1985); Fox, S., et al.: J. Biol. Chem., 155, 465 (1944); Gillillad, S. & Speck, M.: J. Dairy Sci., 51, 1573 (1968); Schoenheimer, R., et al.: J. Biol. Chem., 130, 703 (1939); Seltzer, S., et al.: Pain, 11, 141 (1981)

Formula: C₁₁H₂₁NO₄

Color and Shape: Neat

Molecular weight: 231.29

Ref: TR-B656800

Boc-D-Leu-OH

CAS: 16937-99-8

Boc-D-Leu-OH is a cyclic peptide that has been shown to have antibacterial activity. It is a monomer with a hydroxy group and a cavity. Boc-D-Leu-OH was found to be able to transport hydrophobic compounds across membranes, which may be due to its hydrophobic nature. Boc-D-Leu-OH also induces apoptosis in cells, which can lead to cancer. This compound has been optimized by structural modifications and residue substitutions, which have led to improved properties such as enhanced stability and increased antimicrobial activity.

Formula: C₁₁H₂₁NO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 231.29 g/mol

Ref: 3D-RAA93799

Boc-D-Leu-OH • H2O

CAS: 16937-99-8

Boc-D-Leu-OH • H2O is an intramolecular hydrogen. It has a helical structure and forms hydrogen bonds with other molecules. Boc-D-Leu-OH • H2O is a cyclic peptide with a hydrophobic side chain and a hydrophilic head group. The peptide has been shown to have antimicrobial activity in the biliary and intestinal tract, as well as chronic pain relief properties. Boc-D-Leu-OH • H2O was found to be effective in animal studies for neuropathic pain, which may be due to its amide structure. A silico analysis revealed that the drug substance had a high binding affinity for the mu opioid receptor and could potentially be used to treat chronic pain caused by inflammation.

Formula: C₁₁H₂₁NO₄•H₂O

Purity: Min. 95%

Molecular weight: 249.31 g/mol

Ref: 3D-BDL-2603

Boc-D-Leu-OH

CAS: 16937-99-8

M03296 - Boc-D-Leu-OH

Formula: C₁₁H₂₁NO₄

Purity: 95%

Color and Shape: Solid, Crystalline

Molecular weight: 231.292

Ref: 10-M03296

BOC-D-Leucine extrapure, 98%

CAS: 16937-99-8

Formula: C₁₁H₂₁NO₄

Purity: min. 98%

Color and Shape: White, Crystalline powder

Molecular weight: 231.30

Ref: SR-22237