CAS 169564-26-5

7-Descarbamoyl 17-amino geldanamycin

CAS: 169564-26-5

7-Descarbamoyl 17-amino geldanamycin is a semi-synthetic derivative of the benzoquinone ansamycin antibiotic geldanamycin, which is naturally produced by the bacterium *Streptomyces hygroscopicus*. As an inhibitor of the Heat Shock Protein 90 (Hsp90), it targets this molecular chaperone crucial for the stability and function of numerous oncoproteins. By inhibiting Hsp90, 7-Descarbamoyl 17-amino geldanamycin disrupts protein folding processes, leading to the degradation of client proteins and subsequent disruption of cell signaling pathways involved in tumor growth and survival.

Formula: C₂₇H₃₈N₂O₇

Purity: Min. 95%

Molecular weight: 502.6 g/mol

Ref: 3D-AD21150