CAS 169590-41-4

Deracoxib

Description:

Deracoxib is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the class of selective cyclooxygenase-2 (COX-2) inhibitors. It is primarily used for the management of pain and inflammation associated with osteoarthritis and other musculoskeletal disorders. The chemical structure of deracoxib features a sulfonamide group, which contributes to its pharmacological activity. It exhibits a high affinity for COX-2, leading to reduced production of prostaglandins involved in inflammation and pain pathways, while sparing COX-1, which is responsible for protecting the gastric mucosa. This selectivity aims to minimize gastrointestinal side effects commonly associated with traditional NSAIDs. Deracoxib is typically administered orally and is metabolized in the liver, with its pharmacokinetics influenced by factors such as dosage and individual patient characteristics. As with other medications in its class, potential side effects may include cardiovascular risks, renal impairment, and hypersensitivity reactions, necessitating careful patient evaluation and monitoring during treatment.

Formula: C₁₇H₁₄F₃N₃O₃S

InChI: InChI=1S/C17H14F3N3O3S/c1-26-16-7-2-10(8-13(16)18)15-9-14(17(19)20)22-23(15)11-3-5-12(6-4-11)27(21,24)25/h2-9,17H,1H3,(H2,21,24,25)

InChI key: InChIKey=WAZQAZKAZLXFMK-UHFFFAOYSA-N

SMILES: C(F)(F)C=1C=C(N(N1)C2=CC=C(S(N)(=O)=O)C=C2)C3=CC(F)=C(OC)C=C3

Synonyms:

• 4-[3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl]benzenesulfonamide
• 4-[5-(3-Fluoro-4-methoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
• Benzenesulfonamide, 4-3-(difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl-
• Deram
• Deramaxx
• Sc 046
• Sc 46
• Sc 59046
• Deracoxib

Deracoxib

CAS: 169590-41-4

Deracoxib (SC 46) is a selective COX-2 inhibitor, non-steroidal, non-narcotic anti-inflammatory drug with an IC50 of 70-150 μM for osteosarcoma cells.

Formula: C₁₇H₁₄F₃N₃O₃S

Purity: 98.94% - 99.81%

Color and Shape: Solid

Molecular weight: 397.37

Ref: TM-T0484

Deracoxib

CAS: 169590-41-4

Formula: C₁₇H₁₄F₃N₃O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 397.3716

Ref: IN-DA00ABJR

Deracoxib

CAS: 169590-41-4

Deracoxib

Purity: ≥98%

Molecular weight: 397.37g/mol

Ref: 54-BUP14117

Deracoxib

CAS: 169590-41-4

Formula: C₁₇H₁₄F₃N₃O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 397.37

Ref: 4Z-D-242001

Deracoxib

CAS: 169590-41-4

Formula: C₁₇H₁₄F₃N₃O₃S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Brown powder to crystal

Molecular weight: 397.37

Ref: 3B-D6222

Deracoxib

Controlled Product

CAS: 169590-41-4

Formula: C₁₇H₁₄F₃N₃O₃S

Color and Shape: Neat

Molecular weight: 397.37

Ref: 86-MM3693.00

4-(3-(Difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl)benzenesulfonamide

CAS: 169590-41-4

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 397.3699951171875

Ref: 10-F237584

Deracoxib

Controlled Product

CAS: 169590-41-4

Applications Deracoxib is a non-steroidal anti-inflammatory drug (NSAID) of the coxib class. Deracoxin is a selective cyclooxygenase-2 (COX-2) inhibitor used in the treatment of osteoarthritis in dogs. At low doses, adminsitartion of Deracoxin showed no factors associated with gastrointestinal tract perforation.
References Lascelles, B.D.X. et al.: J. Am. Vet. Med. Assoc., 227, 1112 (2005); Anderson, G.D. et al.: Inflam. Res., 58, 109 (2009); Brainard, B.M. et al.: Am. J. Vet. Res., 68, 251 (2007);

Formula: C₁₇H₁₄F₃N₃O₃S

Color and Shape: Light Brown

Molecular weight: 397.37

Ref: TR-D281920

Deracoxib

CAS: 169590-41-4

Inhibitor of COX-2 and PDE4 enzymes; NSAID of coxib class

Formula: C₁₇H₁₄F₃N₃O₃S

Purity: Min. 95%

Color and Shape: White To Off-White To Brown Solid

Molecular weight: 397.0708

Ref: 3D-FD21070