CAS 169590-42-5: Celecoxib

Description: Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) primarily used for the treatment of pain and inflammation associated with conditions such as arthritis. It selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which plays a key role in the inflammatory process, thereby reducing the production of prostaglandins that mediate pain and inflammation. Celecoxib is characterized by its chemical formula C17H14F3N3O2S and a molecular weight of approximately 381.37 g/mol. It is typically administered orally and is known for its relatively lower gastrointestinal side effects compared to traditional NSAIDs, as it spares the COX-1 enzyme, which is involved in protecting the gastric mucosa. Celecoxib is also recognized for its potential cardiovascular risks, particularly in long-term use, necessitating careful patient selection and monitoring. The substance is generally well-absorbed, with peak plasma concentrations occurring within a few hours post-administration, and it is metabolized primarily in the liver.

Formula: C₁₇H₁₄F₃N₃O₂S

InChI: InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)

InChI key: InChIKey=RZEKVGVHFLEQIL-UHFFFAOYSA-N

SMILES: O=S(=O)(N)C1=CC=C(C=C1)N2N=C(C=C2C=3C=CC(=CC3)C)C(F)(F)F

Synonyms:

• 4-[5-((4-Methylphenyl)-3-TRIFLUORPMETHYL)-1H-pyrazol-YL]BENENESULFONAMIDE
• 4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)Pyrazol-1-Yl]Benzenesulfonamide
• 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
• 4-[5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
• 4-[[5-(4-Methylphenyl)-3-trifluoromethyl]-1H-pyrazol-yl]Benzenesulfonamide
• Benzenesulfonamide, 4-5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-
• Celebra-
• Celebrex
• Celecox
• Celocoxib
• Eurocox
• Medicoxib
• Onsenal
• Sc 58635
• Xilebao
• Ym 177
• Celecoxib

Celecoxib

CAS: 169590-42-5

• Formula: C₁₇H₁₄F₃N₃O₂S
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 381.37

Celecoxib

CAS: 169590-42-5

• Formula: C₁₇H₁₄F₃N₃O₂S
• Purity: 99.7%
• Color and Shape: White
• Molecular weight: 381.07588

Celecoxib CRS

CAS: 169590-42-5

Celecoxib

CAS: 169590-42-5

Sulfonamides used as drugs

• Formula: C₁₇H₁₄F₃N₃O₂S
• Color and Shape: Powder
• Molecular weight: 381.07588

Celecoxib

CAS: 169590-42-5

Celecoxib (SC 58635) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is …

• Formula: C₁₇H₁₄F₃N₃O₂S
• Purity: 100% - 99.98%
• Color and Shape: White Powder
• Molecular weight: 381.37

Celecoxib

CAS: 169590-42-5

• Purity: ≥98%
• Molecular weight: 381.37g/mol

Celecoxib

CAS: 169590-42-5

• Formula: C₁₇H₁₄F₃N₃O₂S
• Color and Shape: White To Off-White Solid
• Molecular weight: 381.37

Celecoxib

CAS: 169590-42-5

• Formula: C₁₇H₁₄F₃N₃O₂S
• Purity: (Titration) 98.0 - 102.0 % (dried basis)
• Color and Shape: White or almost white powder
• Molecular weight: 381.37

Celecoxib

CAS: 169590-42-5

• Molecular weight: 381.37g/mol

Celecoxib

CAS: 169590-42-5

• Formula: C₁₇H₁₄F₃N₃O₂S
• Color and Shape: Neat
• Molecular weight: 381.37

Celecoxib

CAS: 169590-42-5

• Formula: C₁₇H₁₄F₃N₃O₂S
• Color and Shape: Neat
• Molecular weight: 381.37

Celecoxib RS

CAS: 169590-42-5

• Color and Shape: White

Celecoxib

CAS: 169590-42-5

Applications Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous …

• Formula: C₁₇H₁₄F₃N₃O₂S
• Color and Shape: Neat
• Molecular weight: 381.37

Celecoxib - Bio-X ™

CAS: 169590-42-5

Celecoxib is a pyrazole derivative that acts as a selective COX-2 inhibitor. It has been …

• Formula: C₁₇H₁₄F₃N₃O₂S
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 381.37 g/mol

Celecoxib

CAS: 169590-42-5

Celecoxib-BioX TM is a pyrazole derivative that acts as a selective COX-2 inhibitor. It has …

• Formula: C₁₇H₁₄F₃N₃O₂S
• Purity: Min. 98 Area-%
• Color and Shape: Powder
• Molecular weight: 381.37 g/mol

Celecoxib-13C6

CAS: 169590-42-5

• Formula: C₆C₁₁H₁₄F₃N₃O₂S
• Color and Shape: Neat
• Molecular weight: 387.328