CAS 169590-42-5
:Celecoxib
Description:
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) primarily used for the treatment of pain and inflammation associated with conditions such as arthritis. It selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which plays a key role in the inflammatory process, thereby reducing the production of prostaglandins that mediate pain and inflammation. Celecoxib is characterized by its chemical formula C17H14F3N3O2S and a molecular weight of approximately 381.37 g/mol. It is typically administered orally and is known for its relatively lower gastrointestinal side effects compared to traditional NSAIDs, as it spares the COX-1 enzyme, which is involved in protecting the gastric mucosa. Celecoxib is also recognized for its potential cardiovascular risks, particularly in long-term use, necessitating careful patient selection and monitoring. The substance is generally well-absorbed, with peak plasma concentrations occurring within a few hours post-administration, and it is metabolized primarily in the liver.
Formula:C17H14F3N3O2S
InChI:InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
InChI key:InChIKey=RZEKVGVHFLEQIL-UHFFFAOYSA-N
SMILES:C(F)(F)(F)C1=NN(C(=C1)C2=CC=C(C)C=C2)C3=CC=C(S(N)(=O)=O)C=C3
Synonyms:- 4-[5-((4-Methylphenyl)-3-TRIFLUORPMETHYL)-1H-pyrazol-YL]BENENESULFONAMIDE
- 4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)Pyrazol-1-Yl]Benzenesulfonamide
- 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
- 4-[5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
- 4-[[5-(4-Methylphenyl)-3-trifluoromethyl]-1H-pyrazol-yl]Benzenesulfonamide
- Benzenesulfonamide, 4-5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-
- Celebra-
- Celebrex
- Celecox
- Celocoxib
- Eurocox
- Medicoxib
- Onsenal
- Sc 58635
- Xilebao
- Ym 177
- See more synonyms
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Found 18 products.
Celecoxib
CAS:Formula:C17H14F3N3O2SPurity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:381.37Celecoxib
CAS:CelecoxibFormula:C17H14F3N3O2SPurity:99.7%Color and Shape:WhiteMolecular weight:381.07588Celecoxib
CAS:Sulfonamides used as drugsFormula:C17H14F3N3O2SColor and Shape:PowderMolecular weight:381.07588Celecoxib
CAS:Celecoxib (SC 58635) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of celecoxib is as a Cyclooxygenase Inhibitor.Formula:C17H14F3N3O2SPurity:99.44% - 99.98%Color and Shape:White PowderMolecular weight:381.37Celecoxib
CAS:Formula:C17H14F3N3O2SPurity:(Titration) 98.0 - 102.0 % (dried basis)Color and Shape:White or almost white powderMolecular weight:381.37Celecoxib
CAS:Controlled Product<p>Applications Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.Celecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain. Celecoxib is also used in the treatment of hereditary polyps in the colon<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Formula:C17H14F3N3O2SColor and Shape:NeatMolecular weight:381.37Celecoxib
CAS:Controlled ProductCelecoxib-BioX TM is a pyrazole derivative that acts as a selective COX-2 inhibitor. It has been shown to inhibit prostaglandin synthesis and promote apoptosis in human osteosarcoma cells. Celecoxib-BioX TM also inhibits tumor growth and inhibits angiogenesis in combination with paclitaxel, which is a chemotherapeutic agent. It is a nonsteroidal anti-inflammatory drug, thus a beneficial treatment in conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal pain, acute pain and juvenile rheumatoid arthritis. Furthermore it can be utilized in patients with familial adenomatous polyposis to reduce colon and rectal polyps.Formula:C17H14F3N3O2SPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:381.37 g/molCelecoxib - Bio-X ™
CAS:Controlled Product<p>Celecoxib is a pyrazole derivative that acts as a selective COX-2 inhibitor. It has been shown to inhibit prostaglandin synthesis and promote apoptosis in human osteosarcoma cells. Celecoxib also inhibits tumor growth and inhibits angiogenesis in combination with paclitaxel, which is a chemotherapeutic agent. It is a nonsteroidal anti-inflammatory drug, thus a beneficial treatment in conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal pain, acute pain and juvenile rheumatoid arthritis. Furthermore it can be utilized in patients with familial adenomatous polyposis to reduce colon and rectal polyps.<br>Celecoxib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Formula:C17H14F3N3O2SPurity:Min. 95%Color and Shape:PowderMolecular weight:381.37 g/molCelecoxib-13C6
CAS:Controlled ProductFormula:C6C11H14F3N3O2SColor and Shape:NeatMolecular weight:387.328
