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CAS 169590-42-5

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Celecoxib

Description:
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) primarily used for the treatment of pain and inflammation associated with conditions such as arthritis. It selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which plays a key role in the inflammatory process, thereby reducing the production of prostaglandins that mediate pain and inflammation. Celecoxib is characterized by its chemical formula C17H14F3N3O2S and a molecular weight of approximately 381.37 g/mol. It is typically administered orally and is known for its relatively lower gastrointestinal side effects compared to traditional NSAIDs, as it spares the COX-1 enzyme, which is involved in protecting the gastric mucosa. Celecoxib is also recognized for its potential cardiovascular risks, particularly in long-term use, necessitating careful patient selection and monitoring. The substance is generally well-absorbed, with peak plasma concentrations occurring within a few hours post-administration, and it is metabolized primarily in the liver.
Formula:C17H14F3N3O2S
InChI:InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
InChI key:InChIKey=RZEKVGVHFLEQIL-UHFFFAOYSA-N
SMILES:C(F)(F)(F)C1=NN(C(=C1)C2=CC=C(C)C=C2)C3=CC=C(S(N)(=O)=O)C=C3
Synonyms:
  • 4-[5-((4-Methylphenyl)-3-TRIFLUORPMETHYL)-1H-pyrazol-YL]BENENESULFONAMIDE
  • 4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)Pyrazol-1-Yl]Benzenesulfonamide
  • 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
  • 4-[5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
  • 4-[[5-(4-Methylphenyl)-3-trifluoromethyl]-1H-pyrazol-yl]Benzenesulfonamide
  • Benzenesulfonamide, 4-5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl-
  • Celebra-
  • Celebrex
  • Celecox
  • Celocoxib
  • See more synonyms
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