CAS 16974-42-8

deoxysotalol

Description:

Deoxysotalol, with the CAS number 16974-42-8, is a chemical compound that belongs to the class of beta-blockers, which are primarily used in the treatment of cardiovascular conditions. It is a derivative of sotalol, characterized by its ability to block beta-adrenergic receptors, thereby influencing heart rate and myocardial contractility. Deoxysotalol exhibits both antiarrhythmic properties and the capacity to prolong the action potential duration in cardiac tissues. The compound is typically administered in its racemic form, and its pharmacological effects are attributed to its stereochemistry. In terms of physical properties, deoxysotalol is generally a white to off-white crystalline solid, soluble in water and organic solvents, which facilitates its formulation in various pharmaceutical preparations. Its therapeutic applications primarily focus on managing arrhythmias and other heart-related disorders, making it an important agent in cardiology. As with many medications, the use of deoxysotalol may be accompanied by side effects, necessitating careful monitoring during treatment.

Formula: C₁₂H₂₀N₂O₂S

InChI: InChI=1/C12H20N2O2S/c1-10(2)13-9-8-11-4-6-12(7-5-11)14-17(3,15)16/h4-7,10,13-14H,8-9H2,1-3H3

SMILES: CC(C)NCCc1ccc(cc1)NS(=O)(=O)C

Synonyms:

• Methanesulfonamide, N-(4-(2-((1-methylethyl)amino)ethyl)phenyl)-
• N-{4-[2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide

Sotalol EP Impurity A

CAS: 16974-42-8

Formula: C₁₂H₂₀N₂O₂S

Color and Shape: White To Off-White Solid

Molecular weight: 256.36

Ref: 4Z-S-481

Deoxysotalol-d7

Controlled Product

CAS: 16974-42-8

Formula: C₁₂D₇H₁₃N₂O₂S

Color and Shape: Neat

Molecular weight: 263.408

Ref: TR-D245552

Deoxysotalol

Controlled Product

CAS: 16974-42-8

Applications Deoxysotalol is the metabolite of Sotalol (S677300), a potent α-adrenergic receptor antagonist and A class III antiarrythmic. Several studies have examined deoxysotalol on its effects on prostaglandin (PGF2a and 15-methyl PGF2α)-evoked contraction using isolated rat uterus and also in potentiating the contractile effects of Oxytocin (O878500).
References Uloth, et al.: J. Med. Chem., 9, 88 (1966); Narendranath, K.A., et al.: Euro. J. Pharmacol., 46, 15 (1977); Gautam, C.S., et al., Indian. J. Med. Rsch., 76, 107 (1982);

Formula: C₁₂H₂₀N₂O₂S

Color and Shape: Off White

Molecular weight: 256.36

Ref: TR-D245550