CAS 1700693-08-8

JH-II-127 

CAS: 1700693-08-8

Formula: C₁₉H₂₁ClN₆O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 416.8614

Ref: IN-DA00ABO5

JH-II-127

CAS: 1700693-08-8

JH-II-127

Purity: ≥98%

Molecular weight: 416.86g/mol

Ref: 54-BUP03041

JH-II-127

CAS: 1700693-08-8

JH-II-127 is an oral LRRK2 inhibitor with IC50s: 6.6 nM (WT), 2.2 nM (G2019S), 47.7 nM (A2016T).

Formula: C₁₉H₂₁ClN₆O₃

Purity: 98.32%

Color and Shape: Solid

Molecular weight: 416.86

Ref: TM-T7155

JH-II-127

Controlled Product

CAS: 1700693-08-8

Applications JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor.
References Hatcher, J.M.; et al.: ACS Med. Chem. Lett., 6, 584 (2015)

Formula: C₁₉H₂₁ClN₆O₃

Color and Shape: Neat

Molecular weight: 416.87

Ref: TR-J211303

JH-II-127

CAS: 1700693-08-8

JH-II-127 is a small molecule that activates autophagy by inhibiting the function of the mammalian target of rapamycin (mTOR) complex 1. Autophagy is an evolutionarily conserved process that plays a crucial role in the degradation and recycling of long-lived proteins and organelles. JH-II-127 has been shown to activate autophagy in cancer cells, and may be used as a potential therapy for cancer. JH-II-127 also has anti-inflammatory properties, which could be useful in treating opportunistic infections due to its ability to inhibit nuclear factor kappa B (NFκB).

Formula: C₁₉H₂₁ClN₆O₃

Purity: Min. 95%

Molecular weight: 416.87 g/mol

Ref: 3D-ATC69308