CAS 170116-63-9

Z-Pro-Pro-aldehyde-dimethyl acetal

CAS: 170116-63-9

Z-PP-CHO dimethylacetal was shown to be a potent inhibitor of prolyl endopeptidase (PEP), a cytoplasmic serine endoprotease (IC₅₀= 120 nM). It is suggested that PEP inhibitors could be useful for the treatment of cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer’s disease.

Formula: C₂₀H₂₈N₂O₅

Purity: > 98%

Color and Shape: White Powder

Molecular weight: 376.45

Ref: 01-4026718

Z-Pro-Pro-aldehyde-dimethyl acetal

CAS: 170116-63-9

Z-Pro-Pro-aldehyde-dimethyl acetal is a potent prolyl endopeptidase (PREP) inhibitor, effectively impeding the activity of this cytoplasmic serine endoprotease

Formula: C₂₀H₂₈N₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 376.45

Ref: TM-T80106

Z-Pro-Pro-aldehyde-dimethyl acetal

CAS: 170116-63-9

Z-Pro-Pro-aldehyde-dimethyl acetal is a neurotoxin that can be used to label lysosomal enzymes in cells. The labeling is stable and does not interfere with the enzymatic activity of the enzyme. It has been shown to exacerbate neurological disease in mice, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Z-Pro-pro-aldehyde-dimethyl acetal binds to microglia cells and induces reactive oxygen species production, which may contribute to cell damage. This toxin also diffracts light at a wavelength of 630 nm when exposed to X-rays, making it useful for labeling lysosomal enzymes in tissue sections or cell supernatants.

Formula: C₂₀H₂₈N₂O₅

Purity: Min. 95%

Molecular weight: 376.45 g/mol

Ref: 3D-FP111060