CAS 170364-57-5

Enzastaurin

Description:

Enzastaurin is a small molecule classified as a protein kinase inhibitor, primarily targeting the serine/threonine kinase pathway, particularly the protein kinase B (PKB/Akt) signaling pathway. It is known for its potential therapeutic applications in oncology, particularly in the treatment of various cancers, including lymphoma and solid tumors. Enzastaurin exhibits anti-tumor activity by inhibiting cell proliferation, inducing apoptosis, and disrupting angiogenesis. The compound is typically administered orally and has been studied in clinical trials for its efficacy and safety profile. Its chemical structure includes a pyrimidine ring, contributing to its biological activity. Enzastaurin's mechanism of action involves the modulation of signaling pathways that are crucial for cancer cell survival and growth, making it a subject of interest in cancer research. As with many targeted therapies, its effectiveness can vary based on the specific genetic and molecular characteristics of the tumor being treated.

Formula: C₃₂H₂₉N₅O₂

InChI: InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)

InChI key: InChIKey=AXRCEOKUDYDWLF-UHFFFAOYSA-N

SMILES: O=C1C(C=2C=3C(N(C2)C4CCN(CC5=CC=CC=N5)CC4)=CC=CC3)=C(C(=O)N1)C=6C=7C(N(C)C6)=CC=CC7

Synonyms:

• 1H-Pyrrole-2,5-dione, 3-(1-methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-
• 3-(1-Methyl-1H-indol-3-yl)-4-(1-(1-(2-pyridinylmethyl)-4-piperidinyl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione
• 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-[(pyridin-2-yl)methyl]piperidin-4-yl]-1H-indol-3-yl]pyrrole-2,5-dione
• 3-(1-Methylindol-3-yl)-4-[1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]indol-3-yl]pyrrole-2,5-dione
• 3-(1-methyl-1H-indol-3-yl)-4-{1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione
• Db 102
• Enzastaurin

Enzastaurin (LY317615)

CAS: 170364-57-5

Formula: C₃₂H₂₉N₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 515.6050

Ref: IN-DA00ABJV

Enzastaurin

CAS: 170364-57-5

Enzastaurin

Purity: ≥98%

Molecular weight: 515.6g/mol

Ref: 54-BUP06019

Enzastaurin

CAS: 170364-57-5

Enzastaurin (LY317615) (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.

Formula: C₃₂H₂₉N₅O₂

Purity: 98% - >99.99%

Color and Shape: Solid

Molecular weight: 515.6

Ref: TM-T6280

Enzastaurin

CAS: 170364-57-5

Enzastaurin is a synthetic small molecule inhibitor, which is derived from chemical synthesis with a primary mode of action as an inhibitor of protein kinase C beta (PKCβ). As a potent pathway modulator, it disrupts signal transduction pathways involved in cell proliferation and survival. The inhibition of PKCβ is particularly important as this enzyme is linked to the progression and survival of certain cancer types. Through this mechanism, Enzastaurin impedes the downstream activities that promote tumor growth and angiogenesis.

Formula: C₃₂H₂₉N₅O₂

Purity: Min. 98 Area-%

Molecular weight: 515.61 g/mol

Ref: 3D-FE22698

Enzastaurin

CAS: 170364-57-5

Purity: 98%

Molecular weight: 515.6170044

Ref: 10-F807170