CAS 1703748-89-3
:Fosnetupitant
Description:
Fosnetupitant is a synthetic compound classified as a neurokinin-1 (NK1) receptor antagonist, primarily used in the prevention of nausea and vomiting associated with chemotherapy. It is a prodrug of netupitant, which means it is metabolized in the body to produce the active form. The chemical structure of fosnetupitant includes a complex arrangement of atoms that contributes to its pharmacological properties. It exhibits high affinity for NK1 receptors, which are involved in the emetic response, thereby helping to mitigate chemotherapy-induced nausea. Fosnetupitant is typically administered in combination with other antiemetic agents to enhance its efficacy. Its pharmacokinetics indicate a favorable absorption profile, with a long half-life that allows for once-daily dosing. The compound is generally well-tolerated, with a side effect profile that may include headache and fatigue. As a relatively new addition to antiemetic therapies, fosnetupitant represents an important advancement in supportive care for cancer patients undergoing treatment.
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Found 6 products.
Fosnetupitant
CAS:Controlled ProductApplications Fosnetupitant is an anti-emetic used in the treatment of radio-and-chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy.
References Sugawara, S.. et al.: Cancer. 125, 4076 (2019);Formula:C31H35F6N4O5PColor and Shape:Off-WhiteMolecular weight:688.6Fosnetupitant-D6
CAS:Controlled ProductFormula:C31D6H29F6N4O5PColor and Shape:NeatMolecular weight:694.635Fosnetupitant
CAS:Fosnetupitant is a methylene phosphate prodrug of Netupitant. It has a pKi of 9.5 for the human NK1 receptor.Formula:C31H35F6N4O5PPurity:98%Color and Shape:SolidMolecular weight:688.6
