CAS 1703793-34-3

Avapritinib

Description:

Avapritinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of cancers, particularly those associated with mutations in the KIT gene, such as gastrointestinal stromal tumors (GISTs). It selectively inhibits the activity of mutant forms of the KIT protein, which plays a crucial role in cell signaling pathways that regulate cell growth and survival. Avapritinib is characterized by its high specificity for the mutant forms of the target, which helps minimize off-target effects and enhances its therapeutic efficacy. The compound is administered orally and has a favorable pharmacokinetic profile, allowing for effective systemic exposure. Its development was driven by the need for targeted therapies in oncology, and it has been evaluated in clinical trials for its safety and efficacy. As with many targeted therapies, potential side effects may include hematologic abnormalities, gastrointestinal disturbances, and fatigue, necessitating careful monitoring during treatment. Overall, Avapritinib represents a significant advancement in personalized cancer therapy.

Synonyms:

• (1S)-1-(4-Fluorophenyl)-1-(2-{4-[6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1-piperazinyl}-5-pyrimidinyl)ethanamine

BLU-285

CAS: 1703793-34-3

Formula: C₂₆H₂₇FN₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 498.5580

Ref: IN-DA01DQAS

Avapritinib

CAS: 1703793-34-3

Avapritinib

Purity: ≥95%

Molecular weight: 498.56g/mol

Ref: 54-BUP12525

Avapritinib

CAS: 1703793-34-3

Avapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases.Cost-effective and quality-assured.

Formula: C₂₆H₂₇FN₁₀

Purity: 96.59% - 99.7%

Color and Shape: Solid

Molecular weight: 498.56

Ref: TM-T5109

Avapritinib-13C-d3

CAS: 1703793-34-3

Formula: C₂₅₁₃CH₂₄D₃FN₁₀

Molecular weight: 502.58

Ref: 4Z-A-355002

Avapritinib

CAS: 1703793-34-3

Formula: C₂₆H₂₇FN₁₀

Molecular weight: 498.57

Ref: 4Z-A-355001

BLU 285

CAS: 1703793-34-3

Inhibitor of exon 17 mutant KIT and PDGFRA D842V

Formula: C₂₆H₂₇FN₁₀

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 498.56 g/mol

Ref: 3D-BB166456