CAS 1704740-52-2

AZ PFKFB3 26

CAS: 1704740-52-2

AZ PFKFB3 26

Purity: ≥98%

Molecular weight: 402.49g/mol

Ref: 54-BUP16215

AZ PFKFB3 26

CAS: 1704740-52-2

AZ PFKFB3 26 is a mutant form of the protein PFKFB3, which is involved in the regulation of glycolysis and cell growth. This mutation causes the protein to become insensitive to inhibition by the drug AZD6244. The mutant form of PFKFB3 also has an aberrant metabolic phenotype that sensitizes cells to glucose deprivation and activates cell growth pathways such as glycolysis. These effects are caused by activating AMPK and mTORC1, two proteins that regulate cell metabolism.

Formula: C₂₄H₂₆N₄O₂

Purity: Min. 95%

Molecular weight: 402.49 g/mol

Ref: 3D-ETC74052

AZ PFKFB3 26

CAS: 1704740-52-2

AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.

Formula: C₂₄H₂₆N₄O₂

Purity: 99.85%

Color and Shape: Solid

Molecular weight: 402.49

Ref: TM-T14365