CAS 170571-00-3

HYDROXYMETHYL CELECOXIB

Description:

Hydroxymethyl celecoxib, with the CAS number 170571-00-3, is a derivative of celecoxib, a non-steroidal anti-inflammatory drug (NSAID) primarily used for its analgesic and anti-inflammatory properties. This compound features a hydroxymethyl group, which alters its pharmacological profile compared to its parent compound. Hydroxymethyl celecoxib exhibits selective inhibition of cyclooxygenase-2 (COX-2), an enzyme involved in the inflammatory process, while sparing cyclooxygenase-1 (COX-1), which is associated with gastrointestinal protection. This selectivity is significant as it may reduce the risk of gastrointestinal side effects commonly associated with traditional NSAIDs. The compound is typically characterized by its molecular structure, which includes a sulfonamide group and an aromatic ring, contributing to its biological activity. Hydroxymethyl celecoxib is under investigation for its potential therapeutic applications, including pain management and treatment of inflammatory conditions, while also being studied for its safety profile and efficacy in comparison to other NSAIDs.

Formula: C₁₇H₁₄F₃N₃O₃S

4'-Hydroxycelecoxib (4-(5-(4-(hydroxymethyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide)

CAS: 170571-00-3

Sulfonamides, nesoi

Formula: C₁₇H₁₄F₃N₃O₃S

Color and Shape: White Off-White Solid

Molecular weight: 397.0708

Ref: 45-1A02030

Hydroxymethyl Celecoxib

CAS: 170571-00-3

Formula: C₁₇H₁₄F₃N₃O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 397.37

Ref: 4Z-C-032

4-(5-(4-(Hydroxymethyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

CAS: 170571-00-3

4-(5-(4-(Hydroxymethyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Purity: 98%

Molecular weight: 397.38g/mol

Ref: 54-PC1007806

4-[5-[4-(Hydroxymethyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

Controlled Product

CAS: 170571-00-3

Formula: C₁₇H₁₄F₃N₃O₃S

Color and Shape: Neat

Molecular weight: 397.37

Ref: 86-MM0344.02

Hydroxy Celecoxib

Controlled Product

CAS: 170571-00-3

Applications A metabolite of Celecoxib (C251000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Penning, T., et al.: J. Med. Chem., 40, 1347 (1997), Paulson, S., et al.: Drug Metab. Dispos., 28, 308 (2000), Kirchheiner, J., et al.: Clin. Pharmacol. Ther., 71, 286 (2002),

Formula: C₁₇H₁₄F₃N₃O₃S

Color and Shape: Neat

Molecular weight: 397.37

Ref: TR-H946580

Hydroxy Celecoxib

CAS: 170571-00-3

Formula: C₁₇H₁₄F₃N₃O₃S

Molecular weight: 397.37

Ref: ST-EA-CP-C13038

Hydroxy celecoxib

CAS: 170571-00-3

Celecoxib is a nonsteroidal anti-inflammatory drug that has been shown to be effective in the treatment of pain and inflammation. It belongs to the pyrazole ring family, and is also known as a COX-2 inhibitor. The efficacy of celecoxib can be determined using a pharmacokinetics study of serum samples collected from human volunteers. The sample preparation involves a high-performance liquid chromatography (LC) with mass spectrometry detection method, which is used to measure concentrations of the drug in blood plasma over time. This analytical method is used for kinetic data analysis, and it can be used to identify drug interactions.

Formula: C₁₇H₁₄F₃N₃O₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 397.37 g/mol

Ref: 3D-FH23937

Hydroxy Celecoxib

CAS: 170571-00-3

Hydroxy celecoxib, an inactive metabolite of celecoxib, is synthesized through the metabolism of celecoxib by cytochrome P450 (CYP) isoforms CYP2C9, CYP3A4, and CYP2D6 in human liver microsomes.

Formula: C₁₇H₁₄F₃N₃O₃S

Color and Shape: Solid

Molecular weight: 397.37

Ref: TM-T84997

Hydroxymethylcelecoxib (4-[5-[4-(Hydroxymethyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) 1.0 mg/ml in Methanol

CAS: 170571-00-3

Color and Shape: Single Solution

Ref: 61-AMP0344.02-01

Hydroxymethylcelecoxib (4-[5-[4-(Hydroxymethyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide)

CAS: 170571-00-3

Color and Shape: Neat

Ref: 61-FOR0344.02