CAS 170632-47-0

Lificiguat

Description:

Lificiguat, with the CAS number 170632-47-0, is a chemical compound that functions primarily as a soluble guanylate cyclase (sGC) stimulator. It is characterized by its ability to enhance the nitric oxide (NO) signaling pathway, which plays a crucial role in various physiological processes, including vasodilation and blood flow regulation. Lificiguat is often explored for its therapeutic potential in treating conditions such as pulmonary hypertension and heart failure. The compound exhibits a favorable pharmacokinetic profile, allowing for oral administration and effective systemic absorption. Its mechanism of action involves the activation of sGC, leading to increased levels of cyclic guanosine monophosphate (cGMP), which mediates smooth muscle relaxation. Additionally, Lificiguat has been studied for its safety and efficacy in clinical trials, demonstrating a manageable side effect profile. Overall, Lificiguat represents a promising avenue in cardiovascular pharmacotherapy, with ongoing research aimed at fully elucidating its therapeutic applications and benefits.

Formula: C₁₉H₁₆N₂O₂

InChI: InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2

InChI key: InChIKey=OQQVFCKUDYMWGV-UHFFFAOYSA-N

SMILES: C(N1N=C(C=2C1=CC=CC2)C=3OC(CO)=CC3)C4=CC=CC=C4

Synonyms:

• 1-Benzyl-3-(5-hydroxymethyl-furan-2-yl)indazole
• 1-Benzyl-3-(5-hydroxymethylfur-2-yl)indazole
• 2-Furanmethanol, 5-[1-(phenylmethyl)-1H-indazol-3-yl]-
• 5-[1-(Phenylmethyl)-1H-Indazol-3-Yl]-2-Furanmethanol
• Lificiguat
• YC 1 (pharmaceutical)
• Yc-1 (3-(5'-Hydroxymethyl-2'-Furyl)-1-Be Nzyl Indazole) \ Guanylyl Cyclase Acti
• [5-(1-Benzyl-1H-indazol-3-yl)-furan-2-yl]-methanol
• [5-(1-Benzylindazol-3-yl)furan-2-yl]methanol
• YC 1

YC-1

CAS: 170632-47-0

Formula: C₁₉H₁₆N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 304.3425

Ref: IN-DA00AOZ3

(5-(1-Benzyl-1H-Indazol-3-Yl)Furan-2-Yl)Methanol

CAS: 170632-47-0

(5-(1-Benzyl-1H-Indazol-3-Yl)Furan-2-Yl)Methanol

Purity: 98%

Molecular weight: 304.34g/mol

Ref: 54-OR1008279

Lificiguat

CAS: 170632-47-0

Lificiguat

Purity: ≥98%

Molecular weight: 304.34g/mol

Ref: 54-BUP13152

Lificiguat

CAS: 170632-47-0

Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha

Formula: C₁₉H₁₆N₂O₂

Purity: 98.85% - 99.92%

Color and Shape: Solid

Molecular weight: 304.34

Ref: TM-T4381

YC-1

CAS: 170632-47-0

Formula: C₁₉H₁₆N₂O₂

Molecular weight: 304.34

Ref: 7W-GK7558

YC-1

CAS: 170632-47-0

YC-1 is an activator of soluble guanylate cyclase (sGC), derived from synthetic chemical sources, with a specific mode of action that inhibits the degradation of cyclic guanosine monophosphate (cGMP). By modulating the levels of cGMP, YC-1 affects various biological pathways associated with vasodilation, anti-platelet aggregation, and anti-inflammatory effects.

Formula: C₁₉H₁₆N₂O₂

Purity: Min. 95%

Molecular weight: 304.34 g/mol

Ref: 3D-VGA63247