CAS 1707147-26-9

(S)-1-Fluoro-3-((2-(6-(methylamino)pyridin-3-yl)quinolin-6-yl)oxy)propan-2-ol

CAS: 1707147-26-9

(S)-1-Fluoro-3-((2-(6-(methylamino)pyridin-3-yl)quinolin-6-yl)oxy)propan-2-ol

Purity: 98%

Molecular weight: 327.36g/mol

Ref: 54-PC1007722

THK5351

CAS: 1707147-26-9

THK5351 is a tracer involved in PET imaging for electron emission tomography imaging of Alzheimer's disease and cognitive impairment.

Formula: C₁₈H₁₈FN₃O₂

Purity: 99% - 99.33%

Color and Shape: Solid

Molecular weight: 327.35

Ref: TM-T13151L

THK5351

CAS: 1707147-26-9

THK5351 is a high-affinity ligand for amyloid beta precursor protein (APP) and is used in positron emission tomography (PET) scans to diagnose Alzheimer's disease. It is a peptide that binds to the acid complex of APP, which is thought to be associated with the reactive form of the protein. THK5351 has been shown to bind specifically to the pathological form of APP, but not to normal APP. THK5351 has been shown in clinical studies to have an uptake in the brain's ganglia and cerebral cortex, areas associated with Alzheimer's disease pathology. Molecular modeling studies have shown that THK5351 binds to APP by binding at a site between two amino acids known as K16 and K17. This binding prevents formation of an amyloid beta peptide that can aggregate into plaques.

Formula: C₁₈H₁₈FN₃O₂

Purity: Min. 95%

Molecular weight: 327.4 g/mol

Ref: 3D-HTC14726